	   SnapGene      )ÈtggaagggctaattcactcccaaagaagacaagatatccttgatctgtggatctaccacacacaaggctacttccctgattagcagaactacacaccagggccaggggtcagatatccactgacctttggatggtgctacaagctagtaccagttgagccagataaggtagaagaggccaataaaggagagaacaccagcttgttacaccctgtgagcctgcatgggatggatgacccggagagagaagtgttagagtggaggtttgacagccgcctagcatttcatcacgtggcccgagagctgcatccggagtacttcaagaactgctgatatcgagcttgctacaagggactttccgctggggactttccagggaggcgtggcctgggcgggactggggagtggcgagccctcagatcctgcatataagcagctgctttttgcctgtactgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagtggcgcccgaacagggacttgaaagcgaaagggaaaccagaggagctctctcgacgcaggactcggcttgctgaagcgcgcacggcaagaggcgaggggcggcgactggtgagtacgccaaaaattttgactagcggaggctagaaggagagagatgggtgcgagagcgtcagtattaagcgggggagaattagatcgcgatgggaaaaaattcggttaaggccagggggaaagaaaaaatataaattaaaacatatagtatgggcaagcagggagctagaacgattcgcagttaatcctggcctgttagaaacatcagaaggctgtagacaaatactgggacagctacaaccatcccttcagacaggatcagaagaacttagatcattatataatacagtagcaaccctctattgtgtgcatcaaaggatagagataaaagacaccaaggaagctttagacaagatagaggaagagcaaaacaaaagtaagaccaccgcacagcaagcggccggccgctgatcttcagacctggaggaggagatatgagggacaattggagaagtgaattatataaatataaagtagtaaaaattgaaccattaggagtagcacccaccaaggcaaagagaagagtggtgcagagagaaaaaagagcagtgggaataggagctttgttccttgggttcttgggagcagcaggaagcactatgggcgcagcgtcaatgacgctgacggtacaggccagacaattattgtctggtatagtgcagcagcagaacaatttgctgagggctattgaggcgcaacagcatctgttgcaactcacagtctggggcatcaagcagctccaggcaagaatcctggctgtggaaagatacctaaaggatcaacagctcctggggatttggggttgctctggaaaactcatttgcaccactgctgtgccttggaatgctagttggagtaataaatctctggaacagatttggaatcacacgacctggatggagtgggacagagaaattaacaattacacaagcttaatacactccttaattgaagaatcgcaaaaccagcaagaaaagaatgaacaagaattattggaattagataaatgggcaagtttgtggaattggtttaacataacaaattggctgtggtatataaaattattcataatgatagtaggaggcttggtaggtttaagaatagtttttgctgtactttctatagtgaatagagttaggcagggatattcaccattatcgtttcagacccacctcccaaccccgaggggacccgacaggcccgaaggaatagaagaagaaggtggagagagagacagagacagatccattcgattagtgaacggatctcgacggtatcgcctttaaaagaaaaggggggattggggggtacagtgcaggggaaagaatagtagacataatagcaacagacatacaaactaaagaattacaaaaacaaattacaaaaattcaaaattttcgggtttattacagggacagcagagatccagtttatcgataagcttgggagttccgcgttacataacttacggtaaatggcccgcctggctgaccgcccaacgacccccgcccattgacgtcaataatgacgtatgttcccatagtaacgccaatagggactttccattgacgtcaatgggtggagtatttacggtaaactgcccacttggcagtacatcaagtgtatcatatgccaagtacgccccctattgacgtcaatgacggtaaatggcccgcctggcattatgcccagtacatgaccttatgggactttcctacttggcagtacatctacgtattagtcatcgctattaccatggtgatgcggttttggcagtacatcaatgggcgtggatagcggtttgactcacggggatttccaagtctccaccccattgacgtcaatgggagtttgttttggcaccaaaatcaacgggactttccaaaatgtcgtaacaactccgccccattgacgcaaatgggcggtaggcgtgtacggtgggaggtctatataagcagagctcgtttagtgaaccgtcagatcgcctggagacgccatccacgctgttttgacctccatagaagacaccgactctactagaggatctatttccggtgaattcctcgaggccaccatgccctggttgccctctcctggaatagggcagtatatttttggagattttagccctgatgaattcaatcaattctttgtgactcctcgatcttcagttgagcttcctccatacagtggaacagttctgtgtggcacacaggctgtggataaactacctgatggacaagaatatcagagaattgagtttggtgtcgatgaagtcattgaacccagtgacactttgccgagaacccccagctacagtatttcaagcacactgaaccctcaggcccctgaatttattctcggttgtacagcttccaaaataacccctgatggtatcactaaagaagcaagctatggctccatcgactgccagtacccaggctctgccctcgctttggatggaagttctaatgtggaggcggaagttttggaaaatgatggtgtctcaggtggtcttggacaaagggagcgtaaaaagaagaaaaagcggccacctggatattacagctatttgaaagatggtggcgatgatagtatctccacagaagccctggtcaatggccatgccaattcagcagtcccgaacagtgtcagtgcagaggatgcagaatttatgggtgacatgcccccgtcagttacgcccaggacttgtaacagcccccagaactccacagactctgtcagtgacattgtgcctgacagtcctttccccggagcactcggcagtgacaccaggactgcagggcagccagaggggggccccggggctgattttggtcagtcctgcttccctgcagaggctggcagagacaccctgtcaaggacagctggggctcagccctgcgttggtaccgatactactgaaaaccttggagttgctaatggacaaatacttgaatcctcgggtgagggcacagctaccaacggggtggagttgcacaccacggaaagcatagacttggacccaaccaaacccgagagtgcatcacctcctgctgacggcacgggctctgcatcaggcacccttcctgtcagccagcccaagtcctgggccagcctctttcatgattctaagccctcttcctcctcgccggtggcctatgtggaaactaagtattcccctcccgccatatctcccctggtttctgaaaagcaggttgaagtcaaagaagggcttgttccggtttcagaggatcctgtagccataaagattgcagagttgctggagaatgtaaccctaatccataaaccagtgtcgttgcaaccccgtgggctgatcaataaagggaactggtgctacattaatgctacactgcaggcattggttgcttgcccgccgatgtaccacctgatgaagttcattcctctgtattccaaagtgcaaaggccttgtacgtcaacacccatgatagacagctttgttcggctaatgaatgagttcactaatatgccagtacctccaaaaccccgacaagctcttggagataaaatcgtgagggatattcgccctggagctgcctttgagcccacatatatttacagactcctgacagttaacaagtcaagcctgtctgaaaagggtcgacaagaagatgctgaggaatacttaggcttcattctaaatggacttcatgaggaaatgttgaacctaaagaagcttctctcaccaagtaatgaaaaacttacgatttccaacggccccaaaaaccactcggtcaatgaagaagagcaggaagaacaaggtgaaggaagcgaggatgaatgggaacaagtgggcccccggaacaagacttccgtcacccgccaggcggattttgttcagactccaatcaccggcatttttggtggacacatcaggtctgtggtttaccagcagagttcaaaagaatctgccactttgcagccatttttcacgttgcagttggatatccagtcagacaagatacgcacagtccaggatgcactggagagcttggtggcaagagaatctgtccaaggttataccacaaaaaccaaacaagaggttgagataagtcgaagagtgactctggaaaaactccctcctgtcctcgtgctgcacctgaaacgattcgtttatgagaagactggtgggtgccagaagcttatcaaaaatattgaatatcctgtggacttggaaattagtaaagaactgctttctccaggggttaaaaataagaattttaaatgccaccgaacctatcggctctttgcagtggtctaccatcacggcaacagtgcgacgggcggccattacactacagacgtcttccagatcggtctgaatggctggctgcgcatcgatgaccagacagtcaaggtgatcaaccagtaccaggtggtgaaaccaactgctgaacgcacagcctacctcctgtattaccgccgagtggacctgctgGATTACAAGGATGACGACGATAAGtagcggccgcggatcccgcccctctccctcccccccccctaacgttactggccgaagccgcttggaataaggccggtgtgcgtttgtctatatgttattttccaccatattgccgtcttttggcaatgtgagggcccggaaacctggccctgtcttcttgacgagcattcctaggggtctttcccctctcgccaaaggaatgcaaggtctgttgaatgtcgtgaaggaagcagttcctctggaagcttcttgaagacaaacaacgtctgtagcgaccctttgcaggcagcggaaccccccacctggcgacaggtgcctctgcggccaaaagccacgtgtataagatacacctgcaaaggcggcacaaccccagtgccacgttgtgagttggatagttgtggaaagagtcaaatggctctcctcaagcgtattcaacaaggggctgaaggatgcccagaaggtaccccattgtatgggatctgatctggggcctcggtgcacatgctttacatgtgtttagtcgaggttaaaaaaacgtctaggccccccgaaccacggggacgtggttttcctttgaaaaacacgatgataagcttgccacaaccatggctgaacaagatggattgcacgcaggttctccggccgcttgggtggagaggctattcggctatgactgggcacaacagacaatcggctgctctgatgccgccgtgttccggctgtcagcgcaggggcgcccggttctttttgtcaagaccgacctgtccggtgccctgaatgaactgcaggacgaggcagcgcggctatcgtggctggccacgacgggcgttccttgcgcagctgtgctcgacgttgtcactgaagcgggaagggactggctgctattgggcgaagtgccggggcaggatctcctgtcatctcaccttgctcctgccgagaaagtatccatcatggctgatgcaatgcggcggctgcatacgcttgatccggctacctgcccattcgaccaccaagcgaaacatcgcatcgagcgagcacgtactcggatggaagccggtcttgtcgatcaggatgatctggacgaagagcatcaggggctcgcgccagccgaactgttcgccaggctcaaggcgcgcatgcccgacggcgaggatctcgtcgtgacccatggcgatgcctgcttgccgaatatcatggtggaaaatggccgcttttctggattcatcgactgtggccggctgggtgtggcggaccgctatcaggacatagcgttggctacccgtgatattgctgaagagcttggcggcgaatgggctgaccgcttcctcgtgctttacggtatcgccgctcccgattcgcagcgcatcgccttctatcgccttcttgacgagttcttctgaacgcgtctggaacaatcaacctctggattacaaaatttgtgaaagattgactggtattcttaactatgttgctccttttacgctatgtggatacgctgctttaatgcctttgtatcatgctattgcttcccgtatggctttcattttctcctccttgtataaatcctggttgctgtctctttatgaggagttgtggcccgttgtcaggcaacgtggcgtggtgtgcactgtgtttgctgacgcaacccccactggttggggcattgccaccacctgtcagctcctttccgggactttcgctttccccctccctattgccacggcggaactcatcgccgcctgccttgcccgctgctggacaggggctcggctgttgggcactgacaattccgtggtgttgtcggggaagctgacgtcctttccatggctgctcgcctgtgttgccacctggattctgcgcgggacgtccttctgctacgtcccttcggccctcaatccagcggaccttccttcccgcggcctgctgccggctctgcggcctcttccgcgtcttcgccttcgccctcagacgagtcggatctccctttgggccgcctccccgcctggaattaattctgcagtcgagacctagaaaaacatggagcaatcacaagtagcaatacagcagctaccaatgctgattgtgcctggctagaagcacaagaggaggaggaggtgggttttccagtcacacctcaggtacctttaagaccaatgacttacaaggcagctgtagatcttagccactttttaaaagaaaagaggggactggaagggctaattcactcccaacgaagacaagatatccttgatctgtggatctaccacacacaaggctacttccctgattagcagaactacacaccagggccaggggtcagatatccactgacctttggatggtgctacaagctagtaccagttgagccagataaggtagaagaggccaataaaggagagaacaccagcttgttacaccctgtgagcctgcatgggatggatgacccggagagagaagtgttagagtggaggtttgacagccgcctagcatttcatcacgtggcccgagagctgcatccggagtacttcaagaactgctgatatcgagcttgctacaagggactttccgctggggactttccagggaggcgtggcctgggcgggactggggagtggcgagccctcagatcctgcatataagcagctgctttttgcctgtactgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagtagtagttcatgtcatcttattattcagtatttataacttgcaaagaaatgaatatcagagagtgagaggccttgacattgctagcgtttaccgtcgacctctagctagagcttggcgtaatcatggtcatagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgccagctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtattgggcgctcttccgcttcctcgctcactgactcgctgcgctcggtcgttcggctgcggcgagcggtatcagctcactcaaaggcggtaatacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccagcaaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccccctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggactataaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctgccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcatagctcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcacgaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaacccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcgaggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactagaagaacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggtagctcttgatccggcaaacaaaccaccgctggtagcggtggtttttttgtttgcaagcagcagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctacggggtctgacgctcagtggaacgaaaactcacgttaagggattttggtcatgagattatcaaaaaggatcttcacctagatccttttaaattaaaaatgaagttttaaatcaatctaaagtatatatgagtaaacttggtctgacagttaccaatgcttaatcagtgaggcacctatctcagcgatctgtctatttcgttcatccatagttgcctgactccccgtcgtgtagataactacgatacgggagggcttaccatctggccccagtgctgcaatgataccgcgagacccacgctcaccggctccagatttatcagcaataaaccagccagccggaagggccgagcgcagaagtggtcctgcaactttatccgcctccatccagtctattaattgttgccgggaagctagagtaagtagttcgccagttaatagtttgcgcaacgttgttgccattgctacaggcatcgtggtgtcacgctcgtcgtttggtatggcttcattcagctccggttcccaacgatcaaggcgagttacatgatcccccatgttgtgcaaaaaagcggttagctccttcggtcctccgatcgttgtcagaagtaagttggccgcagtgttatcactcatggttatggcagcactgcataattctcttactgtcatgccatccgtaagatgcttttctgtgactggtgagtactcaaccaagtcattctgagaatagtgtatgcggcgaccgagttgctcttgcccggcgtcaatacgggataataccgcgccacatagcagaactttaaaagtgctcatcattggaaaacgttcttcggggcgaaaactctcaaggatcttaccgctgttgagatccagttcgatgtaacccactcgtgcacccaactgatcttcagcatcttttactttcaccagcgtttctgggtgagcaaaaacaggaaggcaaaatgccgcaaaaaagggaataagggcgacacggaaatgttgaatactcatactcttcctttttcaatattattgaagcatttatcagggttattgtctcatgagcggatacatatttgaatgtatttagaaaaataaacaaataggggttccgcgcacatttccccgaaaagtgccacctgacgtcgacggatcgggagatcaacttgtttattgcagcttataatggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttatcatgtctggatcaactggataactcaagctaaccaaaatcatcccaaacttcccaccccataccctattaccactgccaattacctgtggtttcatttactctaaacctgtgattcctctgaattattttcattttaaagaaattgtatttgttaaatatgtactacaaacttagtagt  Y‘   /   >      .   6   B   9   '   .      (      0   (   ;   5   1   7   )   -   G   5   0   -   $   +      3   "   /   *   #   A   %   #   (         &      1      (          ,   !      '            C   )   #      E   .   7   /   #   7   2   4   3   2      4   B   L   .   '   3   /   -      !   :   <   &   8   L   '   8   A   f   4   +   3   /   .         *   ,   ,   2   (            2   '      *   *   *   %      3   )   '               5   <      "   /      '   $      7   )   -   7   N   7   <   &   7   "   3   6      &   #      1   ;   9      "            3               1   *      -      $   5   .   +   7      "   $   &   5   &   7   2      ,   #   ;               6   5   '   $   8      '   (      -   7   %         #   *                                  '   ,   8   >   ;   <   @   8   *   %         '   (      )   $   /   O   7   9   >            "   5      ;   ,      +   2   3   "         /   ?   -   &   1   Q      /   1   ,   (   2   <        / h jŽÚ01\]½ ‹÷øù ü	èéêò4”}/8h®\ÇûcŒŠŒ°n Û ]!$M'_(> à ]kvˆ�äøˆ™2E^ŠÍ .q_ŒúmŽü“	ý	
;
}
ÇüÏÚ\¯ãè�Æ�˜ª±® Ü ^!["6$%¥%'Ý'‘( i Å&	a	^~•!5~0
ZÆ‹ço $·'%(`(.  b „Û�C“¾Úã	i
Ýëó5„äŠíäÍ9i%]¹øÈ¡üdqE'„¦ñ £"
%f%N'å'6 ¹ î 6w�å¤3‹�“–©Ø/>l!±�	 
~
­
.•È¿^™¿¿Ý¤´yº½ÀÛ$X™²Ý %’(B  ùkšF_<Q8â2NYÌæŸy‡›¤¨Gý6ZºÊÛìøaÁFcr¤äš0>ŽV#�X ¯ i!Ž!"\"‘#"$b%¦%?'Æ'Þ'î'9 0 € á å é&ñh`Øûé	þ	ã
–ƒçOžÐÒz›irŒA]î
–¯ CR»9R¢_!A"#ñ#7$R$'^'8(Œ()$)' ^l‰‰µÎ¡r�ný”	<
¦À{Õ,j·O-[`°•é¸co^Çï€Ž«ö!. „ æø®	Ç	z
ï
Á®·ÿ_–;Ä*­26*-Ì¹p�-[ÕƒÃ¦p å!‹"4#J#Ä#ë%Ç&¸' ¦ F[t)â§!	h	m
BFM».ÛÈh/!D!~"Ô"î"#)#p#�#¾#þ%( ÏQ'
ì-bÏ	ð	$kz•">ÃÝŽ¶úe¡÷Ç'ñå L!Ç#&H&‡&&(a(±(ö(l) j Æ�
ºþ"¨7²ï1O¡Œè !‘"$>$š$w%U&0 z…•|ÕÜßD�ä	j
q
˜Î²ç^ºùHëû`—šÐ;œ§· â ò (!A!§!è!"d"1##&ï&'O'æ'( Î‚é¿ÐÛ[1	x	¢	Õ	,
 ˆÈÞ…ßñ!°¿ûžê&›Èýrö#¬#¹$ã%�&Ê';  A ï»¼”Üþ$·�Zrô6å‹î‡@¥øü:á6O£¬î:K^ÉäV{¢�ej£
ª(c"!µ!¤"X#%@%&5 c ¯ $W§x|a—®o	ý
ß&ì>`—åÑ†³ÈÄjŸ°7R¼àÿF…ÑF¡áÐ ~!‰!›!M#%g%r&1 ­ x¢ÓØO‘”ž‘›"‰
á
û
–Mæ‚œÍ4XÐÛŒ™þ²¸»¾ÁÏ%šßà ã!'#·$%7 º ¼ ï ñ ó )N4+—ªïþ w²´¶¸¾v®
/´çÇÀÀ¥µá))hÜÞKp×ÝÞ D$0%à&n'“() þ 7‘éÙô?mU�	!
»_šÉ·’Jî\îµ4 Y³?Ùz ã"=#˜#�$®%&&Ê&ö&- › Ö +P˜Þæ¥ŒU	0�
gÉÀÞéµ§$†Š¿‘z½øMrº 	 S ~ +!v!Æ!##k%»'4(G   ª õ Ã
¹ï=R¬ñ9 œ¥¨«Î
ÊNˆœÔ~‡@+l¯²»ÇËë+=·`ds}>JÞåü›¼Ž�¯$:ÌY "]"E#b#�#ú#s$c%r%§%h&Ç'(5 l�•›G`d°ãyµò¥×øU©Hr[‚ùb0Á+y1"pŽÊ/ ° j!ë!’#é#'$@'R'ï'O(u(Ÿ)0 6±Õ3Z£ºÄÍç4P <ò
@¬¶VvÂŽ7ÖT·P‹ôÂGW‰$�WÏË W!â&ß'÷'D(Œ)- U ¾ Búƒ’òÏ…O¾Ôœ
zÓé=Žþc¾Üínœ=¥§å�×ø?wàdn!�!°"e##$('$ � â æ BiÊ	=£Ç?„«üP1=.ÓœsBÊë?>—°£¶&z'+   o ¡ J'-K™çÓa…ê	—èLvÂÑ{Œã|ÙÍ…SB‘Ãl`! "B"ø$%(%'9(%) M –TÍüÿ	1ø!°�	jïDÊ&¼ o#Þ#8$F$G%ƒ)3 ) 1 ¡ÙP<êùƒòÄÙx¥
ä
\Ÿòë�^cYª³: KSÃûr§#ò#ý#$S$_$È$&/&]&_'p'”'�(•()" ¯RXßÔà		\	e	
`
°
ÜÊàvy!±–¶Ò¹øëè•È1Ã!Ö!$ƒ(‰(/  
ÃÏå4F¢fs“ºÀ-oÑ
§ÜÁb¤°Î-kz´&.‡€µ/p_x=,çò!ó"Ÿ$é'* _mŠ@Š¶âûþ•	õ	=
×
Tc|˜Ö²üPóò.\!êL*í��¬b!÷!ø"è$Ã&# y é ÔYf‹cwŽ»Æ‹	Ä
¸
a“txnd¦ðjæ›ö{ý1"Â"2%ò&A .  "}“izöàoä¯	ç	{
w†”“¸ —<Eëâ+<®3Y°+^´ª.P^PºÎÓ�ÄP"DŸµ‹æ!b"H#K#Å# $u%é%ô(j)% Ô >ç¯NÒÈ	š
ð
RÚ`¢Ì€ËÅð.^ 
ƒ ö`Û- | t!µ$Á&È&¹'�)# ø +-<g>	t
„Â¯BÛÍÑ‚H\Öß„¯MO^‰+ c Œ"¨"ó$ì%y&ç&( … /ùz+
HªËY7ÆÏºöq‚Ìÿ²Ø¤§AQq º  "ª"5#%<&3'ˆ'z( § (À
ÃÛ*n
¥�Ž†ýÉJœŸ{"Ž".#ž#¿#õ$´%Â) GbÆA¨ð"	i	M
Í�Æ}ii e E!”!Õ"ï"#’$°%k&²&}'& '}uãã	@	°	$øCPOQÓ-X/¼/i}–¸ì 0!"*#j#q#ˆ$ÿ%é&H()¥) ’ 9Àë\B5	N	…	¦	Ù	v
(kG4f¤$N�Ü´[âÌ&´)1 ˜ 9¬;d%Caœ{¹à#`qwÞTýÕx=¢·Áøn†±º[“ ¡!š#á$Ÿ%Ñ%Ô%9&a&o&ø&k'ô'ñ( Ê ú ÐRž¬W™qÄ€­ß�ìò5 M!ˆ#1$£$¿%(&I&{&ˆ&'(²(«)( àí.9qc~Ð	ñ	#
'
•
¿
½Ÿl–?#Ó„·áÈ(ó$ æ ª!
"È#Ð#v$Æ%ú%±'ž(÷(m)  (’ç‹�Cƒ”LjûJf½Üð¢!,"‡"•"¹"?#Ö$·%&F'v'b( J
ÄÝ#è[‰§‰6eú« · !’"ð$÷%†(, k c#L×	_	¶	
¡
Í Dmžÿ'ý�j©úƒSoØÄÐ�…¨ ß!?$î%d&¦&Ø&'! Ç5p¹
‚
±»8³ãð×ô2PŠš¢þ¨éWÞ"$›$Í$”%-() 8´–½}˜ËØI"å"x%V&û(' †Ý .vÍ	î	k
™ÝÏ„Š¢Âè¡áFIa˜<Äíý¨Ù ã &!-!B!2#Â#F&í&6( –“Öà@ÎÈ‘³úwˆü›¸)!é!%#Æ$.%$&ð&P'ç' {!J—å	r
ËAÑ+»vüÑ�ñ ‘ ê Ÿ!¨!"`"'¯' }ÆÈEž W_ŸÄÎìîÒÂ– × ó !""e"É"w#ä#m%Ê%'g(C R ¯w²‡›û25G|‚Ç\s2	£	Ö	Œ
!5JSÉÚßw´·Gbt­g›Ÿ÷Y’œÆÏb‘÷tÑ™f!#
# #Ø#Û#æ#o%v&Ž&%'¥() ÏƒWrê ¯Ñ¨±Ü'c
Qã[±ÀüKâAÉë|‰Åx!ƒ!­#Ô##%P%}%Ì%>&½'Ë'Õ'¾(# Ü 0§¦Ày	­Íë"&O�ÁðÔþþ8RÉ\ Ã È!ä%–&œ'(Ä(Û(é( ÊmÞ< -
‰Â†Ÿàò‘ŸAësó'ŒÚs²¬"º$‘&Š'i(E -Gg²À½€UŽÝ(ÿ?¸¼
‘õ1Ù¼ïà1ùý:f;â7P­Éï;LW‹£X¥åX[k’¤�úOi‰Ô! À !#!¤!x" "¥"Æ"~#»# %h'.  B ‡ Ž VðŽÓ•7¼	òUñd‹ˆ¤ò_h|KpÓ”«)d©°xí € 7#Y#ª%Ý%/)7 Æ Rµ!¼@Œ%Ši-~Œ&~Ao©@s½vyÒU;“ª´[v‚$èt×%6C £ ý :"g"¬$%&¹&¨(/ è§Êú‘
[s7æ¹¦ :Î ÊåÄ@f§
< ˜ õ !!6!¶!Ù!"$"r"™"y#¡#$9%A%ó%&M&û&5'# y}ä8.Y‡´ºÉñBE&žÔ!8SÁHG0U œ!7"_%h%¢%s&Ò'7 d � ° ïXbõI	³
þ
gà',â]¨ Ze9–Ò@ÅÌøÖ±Ðà6´†¿Ò¼ Ñ !Š! ##„#[%»%×%«&'|(_)2 Ø €¼à	¨-è³t	©
¬?aãF¼kÙãcKO« $JR¦ú3¢Þ+:âj s M"Ë"N#ä$‰%4 %š1˜¯¿Í)	R	p	€	X
8xgv‡í<)*Øë˜æ“E a„fô½Tá*G¼SŸ »!¾"%'3  a g \u÷‡˜Ù[‰Ÿ’^ŠölûÆÜçƒ‰ûÎ |.7[çÆb&ƒ‰~—\!5$	%e%Ü'ä'$(^(2 ¸ £´è%;P’•×7ð žâ
NzÔ+�5Y¹ÉÑšqEb@”	®ÿn³¹¼¿Úh!�!õ!#ð#Q$]'Å' ¥ ,­€
¶yÃ6ÂÜ)N¸L�ùÂÚÇ&ä!}"�"(#4 @ ® yÔV»è`œÏ#Z–p
ü
�q—ð_?Ç�æžšãêÇõbÐ›àá @!}!ˆ!š!´!"0#¸$â%"&É'B ¬ » ð ò ý *M¡Ò*NTîóýÿvT³µ·½uŽ
à
³LåÈ›¶´I¦´Úí¾�·ÎÝLoÖØÞ ß â!"#<#—#­%L  T © ½ ô A	5c‘¯¸îñ«ð„Ôx¢´¹Ã3¤§ªñ;Í
«µèMÓÖU�†Á*k±½S¶*<mŠI*o®vËßcÉV!m!a#d#è#ù#q%g&á&''N(ž).  n    ØO;ø,J˜æSÒÃw¤
0û¯Á-‹âêØê%ÿA�ÂÂúqÿ!Ý#ü#E$^$÷$F%µ&o'”('  ÓXÂä3EeŠev¹¿,¯
Ð
—±yûò†-ß.s0iå<õzò"1%3 ÷ ÿ ’*fy®õynMÑ	=	™
vÙAG¡ËÊÚXáï¯Å]õþ!´@LˆÚb { G#$´$%t%x&æ&2'y(/ ‘ 8'ê&|	aÂÅÚ@ï	4	M	„	¥	Ø	#÷jO£|h#€.…³ZI›ž·i#‡$‘$¯%³%j&Ë&Á)- — �:ß8V}‘"
c~¼Šžp`›¸B“Kviï¶¹¡†">#‡#™#u$¢$à$¶%¾%Å%'&n&÷&u'ð( b¸µ	
Ì7³
€‚•çˆ5dÏ„ª Þ!ä"“%×&! ’Åÿ -uIí	ÊÜÍƒ�¡*Vžàv‡uÑìð,!_"$#Á#Å$l%E&®'5(: Q ®v†VqÝ
14;~�¥Æ°&r‹
 P4Á¬v¶F%f‹À{ˆ�±s7Ð˜[ w!‚!Ç!	##×#Ú#O%�&$'›'¼'(½(Ã(Ú(< � Å ,Q±ç¦�Ò?Éù‹‰�
hñ,Tð0Š}¸ßn¨?uÑÈ’‘“ù¯çNsÓ	5 
    ¿ 5!"q"Ÿ" #©%&L&§(.)& œ × ™ß7†á; (§êdE¹Ë�Ó¾ù/»*T i ½"#ƒ#Z%^%8  ? ¤ · [—Uº$:çï�¬õÅ*ˆú^ÂÈÁpÆDMaå6?Kæéô%aÆÙ}?!|!‡!™!ï#4$P$d%!&\'È'Û'ã'L    « @Ñbð2ISdíòÓå¡³¸Â2¦©ð:Ï
ªLÒÕú…®),j°³¼ñRŠ³Ùì,l‰~×ér½�$¶ä;@ÍbÈl!þ!ñ"c#–#ø#û#´&�)' ö &`­ÁÞ<	L	
Ë‰�	NAW{àæý-„Ha Ý!F#t$†$s%²%i&m&Ö&1'x(8 Œ ­‘Ä,…>t:ÅŠˆŠ
ÿOSÛ«'u·mÌ>¸etÊ)Ðßuœ�°®Ï)4Z h "^"ž"‚#Ö#¨%D&(¼(Ù(-)A  ¶ �–a#1_Àìäî·ïô9KÄÑÚùªt„­ùV]iQkCÉä,#Ø3Ç` g >!k!{!†!˜!ý!•#î#O$…$C&0'Ú'w(»(Ø(œ)f mòóHIJefgs0Y^ÈÉª¶îóCDPQX2
E
3¦ÏÐØÙVs¬Åƒ„�žPÎÏúûGHƒ„È’“”•ÂÃ2qr�z!…!–!—!Ï!Ð!“#”#ê#ë#ì#í#($M$N$m$n$@&A&B&/'A'S'¿'À'Í'×'Ø'Ù'P(Q(v(6)4 nôKhnÆºÊFzÖùIRYªk	3
F
e
4§nÆK\Ic…’3š�Ë0 Ñ!h$o${$Î'ð'R(Z(·(Ë(Ô(7) )®)+ œt±Z«4E$	šWÁIÕ­…ŸÐÕü1ƒ–Äzs± ì!¯#³#)$”$U%B'T'Á'V(ÿ(A){)»)3 O4»×«Ý	b	l	à	
G
f
�¨#gÃ‹�L]¬×“õþHXŠC4ž`šêÌw È p$©$%%Ï'ñ'E(®()/ ³ iÇ»C�5Q¡#Úø­5oö›8JQ†Ã%‹Õ0ÐG!R%Â%ã&''à'ø'(S([(¸(À(Õ(¯). 
 õ7Lo¥²Ëi‰{‚œÅÎèú=JSZó
AJ·/WdŒ{X\,1 B � i$›%š&Ì(b)�)¡) o¡ÖG[¤4
FwÎÇU¸2›ç~‘ Ì X!Ò!|$€$°$8) “ÕÃò8
‘”>ª‡—ùË7Ô c!$$Î%&C'* ¿ „u²[†¢öP¿ñö)FO
{>ƒm
¿ÝîÖÂ„3Åæ+{táL o!#f#°#Â'W(, V CóIó±5 %	R
›�Jÿ†ýo6ŽØ7@xekÀƒ ×"R#*$•$û$%)'U'�'™( ) )()B)¼), û�ØÐ¬ƒ�
Ôê	8X½ÂÈÖå®d Ñ�2¦ï¨Ûí² �!í!±"é"´#V%Ò&'2)|)2 ‚ Þ ã CAjØ¬	m	‘	Å	á	
g
¤@X…¬ý$\hMØöZßì8˜+5Ÿ¡w¤  &…&‹&¯(( ç œP¼Þc	‰	>È©>tŒ�V€­Ô'tË‹±°ë	Íx É B$q$Ž$&%-&2( åH
‘CÄ2^ÝÿY€;N¦r!,#7&{'ò'F(	))²) 5G	~	Ë	*Qež/�”ICw@?Dòan›ª$©&·&ë&Ð' z(Lw6KR¢$íùë	Ë
	¯w	s ²!o"Þ$Ã%ä&"'\(Á(2 ¢ ´ «l.¸¾DÔô	!†žÛˆ
˜6«Ó÷Ãä‡}ÄÕÎ˜ÄÖÍ1¾^ a!û!ù$S%˜&'á'T(¬(¹(Ö(&)' ! p K©jx š¶¼bE	†
&®é`œÒñó|KRÛì&†C’mËÑŠ$Œ$(>(°) Èè‘0rMp9�ÇÚQTŒO H!"C"%)%''ù'ÿ':(O)* ¦Ìm˜�ÉéûýÑ	Y	
]
¸Ð§±MîUðõˆ's 3¡ê2 Ž î œ%Ú%<'(*(¢(¢)* N )8pý³Ôj|ƒÆÏkÎ>Kg{	²	¿	ëeÕSkYp°Š Å #ß#G$j$˜%(V)c)Ž)* öŠU[	 
é
(2úôXùõŽ
$h�âˆ:ºl#9$Ñ$H%(@(J(m(Í(Ý(r)‘)—)§)%  M—dÉTô
BK0"RGQÔF(/jEË1|½]-³C 	&›&Û&ë(„) M=¥nå‚¹	¦
`È¢ì3§~ƒI¾ÖàEoÍ Ó!Û"ý"æ%^&Ž(3 µëú Âó\9	B	Ý	5
G°EÏíó3Dº5«Ã(kk?Ó 2!Y!Ê!J$}$±$L%&~&9'!(–(Æ()))9)) * 2 Úp„¨HÚª	å
]bV¹_d´;LTü’«�"s#ó#$T$�$À$É$%`'•'ž')' # r 2¢Q¢Ü×Åy¶
x Ï~TŽ1ZœèE”TÄs8 P!Ð"¨#þ#`$Ú$…%�%0&®&q'<) ÌYÖà¥	f	ú	9
x
’¦Ýâ•½Ë¬·ù¹9J!V#$%'ì'Š( ”aÄ‹wz"È—´ºì28Q Ä!®"ö"%$ÿ$&  Õá
	]	®	
hoá«ˆÏû˜²ÓŽÌ–ÉÖB/$Ï%D'„( °íSóP	a
±
º
t�?õSúIVéÕ d!×!v"â#$7%ñ%5 …Ðæo^£¶÷Qt”»Á*jpt|�õ*î?„•±.ˆ{ù“ÃÝC¶,`Ž-T!ó!#:#g# $à%Ã'<  = Š YÄÖG\£g‡€ˆÀ÷2AGNP
¨Âlµ'ÀÞïˆÌ×n�…í4Ùç)0y‚´ò>_¬{@ J Í!±#X(µ(É(Ò(¹) v³ò.œ7	‡	¨	Û	c¥	ï1u~|quèM ˆ p!+& '<(k(" 9 ; Z \ À Í 5_†“Ò
‹ÝÏ ¡n/ØÜÆÓ[]|~âïH ô"\#ê'/ v D‹Â ãÊ%&	d×R ¡/p7°"�ÛëÙM+Üôu ˜f­ä"œ 	!##“&£&Ä&‘'æ(!)\) W ôJü>6Ý
œHOK˜Ú8ylø!Ø"S#^#ü$¶)' E ;`n‹ôD¡ÿ-	–	ž	>
ß}r³;Q‡ô]]î
g]‚�Áù"–$€%*'¥'š(C)½)$  A·²•ö	S
Ø
U�™Äý¤óþ’A1c„ !:!+$é$�&Î&V'„'û'()))v) j¼ž
Ô
I™Vue§÷‘!>"Ã"¸#+%=%ó&'e'7 6 ^ ” Â ÕžÙ7gÑä"­hÂ	/
ÑŽ£¾×6x¡CÉÒ· &3é©Üor—çX€¶ä÷"µ#¦$%W%Ó&«'3)Y)) z Œêd|Œ	Å
ŸãYÒ9¦ežJb®Þyb	·ñkÕÞœþ³ E"‹#Z$¼$(f)})- Ï ê üZàx„�Ç
Õë
9m"¹ÃôÉæp¯ý”§ðPîñ|î!2"²"ê"3%€'Œ'J)Q)7 ß iƒ�ÄãD€Ì%-B¼ÿpÙÿ�	’	â	
h
|
]3ìÙã4[g	$÷Y úpDÅ‹¥¯æm ð ¢"¶'N   /  ä j�¨á1=MXgkËå°	è	¬
-x•¥‚†”£¿æ]i˜¶F¾¾ÜN,y£÷Z`_hÀqí™·/BQ]ºUx"Q¡#Œ"!$>')#)7 ƒ ÎEå÷së(Æ	
ÀA­¹þýEj!)=¬1±,µ,- Ôö‚¥ðg #I#o#œ#½#Æ#=$™$v%ê%ý%†&Æ&°(õ(k)< #~”î{¦Ûý­¶0	n	w	¡	Ô	+
‡Y%=¯÷û²ú±à«¯í96Q_z–€»Ï¢©E ¶ ¦!ç!c"#L#%&q&Œ&& š Õ Ýè��šfº�‘Ìè3Wà(±¼÷ÿ>Üy } u!â"C$�$¶$É&ß&m'º'3(7 ŽÂ°ÎŸ½OÓ›
ñ
?ÉÒ÷Tuq}?�b�®ÆÕOó/<V_|=ÀäˆŒÝ�÷!Î. Ê D#€#r$ö'(C(‹)" ( L I‚É	<¢>ª÷ ñ<ubÌ>=X²„ŸJnk¦#$'%.&“'‚)3 x è 	?úQWºÓß	[	d	Š	ô	
_
Ã
SÛa£¯ÍÛñ	u  ¥ê)çw”ìš
+aæ!Â!$ž$ç$Â&‚(6 - Ó ,.;=hß*ãQƒ…“’©D;XÎ ÿ�ËO]O¹×Þ®£OõNP]_Š* , s!§"©";&À&ó(i)€) ¿¿A?	u
'€¤Å3NeP�ÒWh•üád z"�"-#ô$è&|'G(
)¤)³)& É ù 8««æ&
¾
�‚_ÞSƒIÛ<àm…°ëZ# 4 +"Ï#ž%Ó%8&z&j'ó'�(ª)# oI
Ã°C�&üÜ¼ÖZRn|×¦§Ãˆ§¶ H"Ì$í%c&¥&,(ú() Ì	@ÇÿÐÁÃEÁ� • é !%!!"È"v#É%ì&1 Û /¦ú{®IRÙžÌê³âZasž¬Jšárò‘@NÙaýQÈÄÂ «"Ó#"%|%=&•&‰'¤(è(; † FU´ ¿�'6>cØ»%0r9ex9ÍñŠ³?Zou¤äZ¦Òœ¨hwÖ$Bì£!6#}#«$%Ü%¸&ú&4'9 »0,(	H		ãfw+f«)ŸâY8•ð»÷DÕAƒ %eó b5NS³¥Ý9Rr ž » 6"ã$¡%Ö%ª& 'Ñ'{(^) öÖ+Yúo
>-�³!|"�"/#](" ¨ ü ÒL:�®Á÷)DMÑS£Ì
ß
°xn­þÊôn `#]$ö$¬%M( � )a{Äx97LÐî´	˜

g
‡²Kƒ� ß$µ%Ä%å&ï(À)Ã) P uþÜ%ì	6¦‚�t‡r6—ï  p"#Ÿ#À#K&#'Â( £ ¬+Tc1‡‰
&Måˆ~ÅÖÏãÅÎ(ð"3$±%l&³&â'3 µ mr/¹¿ÇíEÕ
í8©#	j	™JÎ¬ÔøÄJhj‚‘‘™×2_ f •!ü!g$l$z$„$“$T%.'U(º(×(z)›)­) 	  B�›"Ü�fÍŠš~_[+ v Œ Ç F!¯$š%Á%™&'­( òH~ðõŸñN
7‚Ç	©6j¿‚ b!Ö"#Q#ú$~'')1) ~›@äF	}	�	W[B�&ÜY:M~¯+#�$ &Š&ê&±) ªkyÿµ·½vJ…
‡
%òÆÚÔ—Ì½ú!‰$‹$«(1 (l—Ècf	X	±	¾	è
'ùêóQPÓôLRáí.ô‡0r2¯²¹í k#Ð$—%(()(?(I(¡(U)�)¦)* " q Lmä�A	¯Da}CS¡¦0'j½ßjD“nÒ7 1!O!€"Ï"Ú"ü"r#I$¿$K%„%}& ()) ì¤	O	­	w
sgŠŽR¸HUÕP I!U#á#$þ$%'- Y ‰ Ì XÕ]…’1@Mi›6	†	§	Ú	sô)íø×ÜmÛ}�ñ{«îz9#[#ß%*&;(´(¸) D :ÁÉC�	Ü
NQq:¯‘f\ã¢&Í&¤'ú' (u)µ)$ 5 “ éÁ	žlH�5¥BÈ¶%IUOa~–ÝWµö"="D"Š#¥$%*%'d'P)X)e)5 ~ §$,0<WÊêü'þŒ/	 	Ó	*
,¿�¢¾üD\µ ½(x«_¿ùöy•ùoC  ï n#›#<$˜$ü%p&='. ' ™ �ùÍ™žÒ	Z	ó	
^
Â
e¹Ñöt|çaßNU{¿Wé(I»*=åá"C#¥#$l'õ'(B(+ È :nâ%
P&¨Žd�ÕþVmÖ¥g”¸Â‡¢ê\3 Î#�%Ò%:&b&+(œ(ò(ù(£)©)7 Tº¾Œ­=âb�²ºá$(`r«ï™ÔñÂ‰>t£ã4R²vÜ8Ãë� ” è ¢!Ò#â$ %È%Õ%Û%ù&ÿ&£( O û Ñ`9­öCÕÐXÏ³	—
5=f†qó‚#J&L(¿)" *SqŸ}Žšï0ì���5^Zâ'‹ Æ 2$f$k$y$®$™%À%-'š)¬)$ þ´kÇle€|	�	ZÅ%Bà®®±¼6 N!Î"û"H$J%ƒ%|&‰&(((( (ª()�)& Ë „?Lhš£	À	ìr÷‰AÖTl®|·Gðíõ<"‰#à#¤$%)&¡&c'£'³(W)d)t)5 } ¹ø‹Vá<Ò	ò	$
)
Á
+O¾á€¡õû€æ'_ªÔø˜¾lfâBŸ)Ûç m#Í#Ñ#$;$Ç%û%A(ø(¨)& _Bî/ëd	–
4Yö@$�{…¶F]­á�»ôe$x$I%‚%,'¢'(K(Ÿ(s)™)7 ·¸^÷:;\Ñ	(
À
)*3 ú%&ijŽã÷¸jk=E‰ÉÙÚ€«!¬!É#Ê#Ë#Ì#	$:$d$w$»&¡'	(
(Þ(ß(à(á(’)˜)2 bpFr]	˜	
@
ê
û¸m—�kuä5¹>„Š &œÊ;„’% ¥ ­!"P"i"
$Ò$¼&§'²'(n(Î(â(n)“) N˜Ê^„Õ kÝÌ!Ý!'!X"ˆ"–"Ž#Ó$¸%R&J'w',  =#á‡esUC`ü1˜D•CSMl0F….<_E£´º"W$×$&
&˜'¨'(Ï(ã(o)”)# )GL€Œ#nGqvxüg?Üæñô2‹¾Ï^Q"j"@#$œ&½&Ü&G'³'ì(; G cq “è	™	
A
ë
õ
k/¹
ø/S‘HR�öæå)6kºK¾¬x'}�ôøËi…“& D ¦ ù ÿ ®!"-"&(c(o(E)…) ¹O_"Æ|…¦£ín4”hŠÞ7¬ Î ! !Y"‰"�#S&K'�( N­ËÝƒù
ZÅa$éŠÐl„¨JfpûÔ!x'‡( oK
“
ÞÉ!\¨°¸ !"“"Ü"Ô$ñ$ç%õ%ø%_&†' >™¦æº	§
|6Ö>ÌÞ¿Í×á"F©"(!!—"þ"¹%6 l žVd$¶âìˆt¢
a±´2EnŸ 9îþ™4„T¬ÄlÅ.ØŽÀx†µÔ3!Z!à!„"»"$²$Ã$M%&e&™'"(5 >$!MÃôVØ	:	`	Þ	
6
DHý!(‚ôkªNE'1pç	å`.F<!Û!ö#K$~$&Ð&	'Z'(—())+)' ûC	·	ÎEDT6)Gl†C=¤©  m"@$Ø$&ƒ&§&Ù&7':'ý'0()):)p)•)$  ´]fø	FÐ–vûm»Ù€Ñ/@> † š !8!Ë!t"-$X$;%ï%&©'Ç(Ð(ä(8 + ÌÛì6Cq©ºK�u›èoL9WºõñQo‹¿`e<µ@õÿ¿Ð_MîýXet#{#$œ$Ê$%¾&Ý&´')‰) 3 sH«	ƒ
Ú
æ
�$H´Ø›ÝU• $‚$Î$•%í(x)' …*M^¼-»¨äõ3yh£çò3«¬÷ ß"A#£#$U$Ÿ&ý&H'a'–'Ÿ'()( ÈÊêq©«IÛ	
 ²crtw˜<"ýŒ©<êì“&"R"k"‚"ô#Á$�&X'.( 3d”U
ì
’÷ÿL~[~U†9 ú ¸!."J"Ñ"©#†%&Z&¯&d(- s rÌÆz	

B
·
È
o0]’ÐS©‘—¾yçæ2žéÌ•”E § Q!¯!›"æ"Û$C%Œ%�%r'ü(7 $ ££!Øü—š	ö
WlµyÕù03¡Iÿ	UM*l$»¿"­BŽ‘�™ÌõFÅ'  !("ÿ#a$y%O&W&(†)%  H RÝé9ºTYe �šž7Æy(.Ùù>M3jt""T"ë$&1&p(=)F) ‡/`û	:
ñ}“ãÌ­¸â‹Å©­ Ú Z"$%¤%'L'�( í 5×š¾§ë‹
£•b=î8WW @"�#a%í'7(‹(# PZá¦ 	g	Î	ï	l
y
î
#:”§îËod€ ºä !.!C!K!Š"Ó"í"3#Ã#&G&T&* ºÍÞw{ÞÇÞ†– ¤¾Ð…Ãé5N¢GJ]úU™:ißþ	Ï !!'!W#«#?%î&'  (O—×ˆú
æÆÏ[#‹˜(…‰ýí3gJq¹R *!Å!&#/%j%%&õ& ‚”›<ê›¶¦ûx»Ö#œ9ê!¯"&$Q't( A•Ì„[ÆK0Œ{É©ÉÇ$ %&\&y' ®áb’ÞÅÖ
b³%Éx’´wµÑm÷KüÕ!ñ!0"Á"÷"ñ&è'ˆ( !|æ	s
êÊ]Ð³G©	‚±ÍÒ€Cž¹ "a"ò$è%‡' â¯	L
Ì,�| ë “!±& p˜”
Bßp"¬Òü¼ÔwÀò’ ! !©!	"”"¸"0$Õ$Ð%ù%`&E'°' 4"KÖ	^	
 
liùâó‰™ý—Ê×VùÝ"ï$ö%'…( Ç?–‰ ÍíûÃüÖ Ø ž!ã#-%'f( ±ÉšlFŸ§b
�@öXÅ€ïÎÓêe!å#n%Ë%u&Ô'h(' fT»	»
}¼T:g©ÃJW#Wˆ; — ¢ ô ü !!!Ø!#"9"f"w"˜"Å"x#º#$8%ò%g', ~îç²¾ÌôQ	s	W
¨
²
u7\-× X’?D`ÏßÀØâGJª#)IQ2º!L"Ê"ÿ"ˆ%º%'8 ` f t†³Zˆç6_Î]•kŽpµyÓÛïx¸5™{(œ·øZ“­ÅâmÆaÙ‚ˆ–[!g!Œ!ô!"#á%Ä'#(> S m Ÿ Ÿ×W ·ãí‰üdƒRuu¼Â+t�
£
²KTŒ–äšµúH…;ÞéH-/u�ÁÁùyÕU!á!!#;#Ü#ç#E%p%f&&'; – ex%œ·|3	ƒ	¤	×	"bu}Øöi6@Fo ²ÊÙ¢u�”®Ä"hôcÎ¸‡š¶© …"h#†#$¡$³$%’%½%w&t'< Ä °Ñp3H}€¤Èø¯qð+ï3…à/:‰ÿ|EcD U�ÇÒÐë�’øæ.Ò¾ 4!�!¼"##Ù#Ä$N%Y%]%&�&š'­'¦(@  > ‹ ?Z%Ð„9HsæÄÒ‰²ÁÝ;	K	
©þR)¶(zÁßð‰²ÀØoL(5èqtèƒµó?`­a|GÜ!�"Õ#÷# &Õ&[',)8  ñÅ"X]ë©ø3BHOW1
D
d
2ÃmÀƒU\«œOÍÔFB‚ÇãÆ=!y!„!Î!®#²#L$?&¾'Ì'Ö'Y(¶(Ê(Ó(þ(5)@)º)* ² ¤Nhˆ�Ù÷	a	ß	
EI".õ«ý1Bzæ}Š™éÔ/A $¨$$%Q%
'(¿()a)% ×¡°õ‚(Â7
Q
�¼äl“Á5†î2Ú*
Êì6K Ó è"~%Í%&Ñ&�'˜() Ý ˆ	Ä	)dsUvÞ7ñ*m vÿ¥ q!A$,&6&„&¨&1() ¨wó /�ìD	Ê
q®_ªÒðëPrÊ N ] ±!n"Ý$—&!'þ'=(N)' üÓjÈÐ	z	
\
Ï¦
FE#gÔ'Ti‡ÿ9é‰ Ä Ù%&Ú&;'(l(Ü(ê(q)–)( 1´Û§Á8	©	¸	Ü	µ
_Îì2¹4}‚ÂHÕD>SªÉ!Ù$%Ž%å%­&8'�'Å();) Ë`ù	¹
¥án¼Îú«Çô³�8Au"­"õ".$6%ð%ë') 8 : < [ nµ^‡ŠŒ”‡ î0’ËBìtØ(�³ÒZ\^}? G I ‡ S!Ì!'j(È(Ñ($  u ÿ=$”,	ÞGÃ—£\ ÙÚÛót	0—!› !9!##]#€&’&ƒ'å([)/ ] Á Î 6ißã!g{
.
Ó
 âÐ!¢Ñó8owü˜è­Ýq¶Ôãð·#Y$»$<%‹'ª'~(I)O h‚ŒÃÍâíDä¥ËŽr»ÚþLfµv	«
	å2i½Û¢ö0úg±p°f#®ì¶AX ,Ÿõ\¹T¨!Š¤®åïfl ¥!"¡"##¼#%Å&µ')")7 K w HÜÁ�V�¹;¡=®öSÚpð;2ò;<aã=‡Ü<Œ¤öæv“žm™jþ
!Á!#$�$æ$Þ&’'�(Š)9 , Ò ¾7ª¾ªÞ) @½
‚’œ%û£M:»WORŒQ{ÊÚN¦Ýl­ûNôàY" ) µ *"G"y"¦"Ë$¤&¿&i'h))> Ú .E¥³&'	evØ?×éáXqþ8dÀà8�ð$MdYMY¥ÀÑ`üPgÇÕ#� Á !$!5"Ç"u#|#!%{%”&ç(]) � õKtý�8Þ
,œm¬±5m–î  _#\$«%î(  ñì7IŽe%LÌ‰™Ig¨*u � P#ƒ$0)y) ?–IW	½	„
ç
VòA Ù¥óiÞ9Lq1ù!Ù"¾$Ï$–%T)" 4 C X ˆ WÔœ	¬	Û
�óPŒµÛH`}Ô•Vezªy8#T#Z#$ý$Þ%·)5 & Ç SŒ½#+/&‹.	Ÿ	½~[s´�'c¼ª^¾zÓÁV¤”è“QHéu7<Âä à"B#¤#—$þ&›( õ�™¢Ž	<ˆA4ï&­;"Í"ú"­$% &b'©()¾); | ao¶]AEê 	—	?
Nà·å^t©ö4—z½i<µD\eƒ¬%›Aàžƒ‘Ø¤ O"h"$$c$�%º&+' '¦'(, F <"à†_j.	÷.BRpõåw«ÛåówÎÜó÷ &h^Dø þ W"�#V$&Q&I'—'(D) ¬¸Ü’
ø
Y!{Å{5¥=mÏ“Ë¯g¨!!!"ô%…'+ �U³÷	³8u&æBä-×¿-w= … ™ !7!;!Ú!l"s"ƒ"õ#$,$Â$:%‚&Ï&6'Y'ü'/()*)2 ÉËéëBr¨ªJÙ
tšç,Kºsô§—;n¾!;ªëíd”  ö %"z#¢#ž&ü&W'(w)ˆ)3  Ëû–~

T
Ç
Vn\‘Ô2Xd¨þÿxL™�#þ!ÅA��-=L2·!"'"S"š"ê$B%‹%&N&Y&" ì 4zí
½ð9“êÊ	 Mc\ŸTVV ?"Ò"ì"ª#>%`%£%&' '�‡‘šÕ
å;JÅ/²šZµ¥v'Õö"ÈIð!/"À"i%[&ô&s( 3Ÿ
kéøòF�{¿Uø’!·"î$°&/ ek~•±½Ër	V
[,ÿWˆ‘»C9f¨ÂIVûHP1‡: ¡ û �!¹!8"K"Ä"¹#,%‡%t&'f'Ó'e(? _ e • ž Ã sÖŸYcÍ®{‚	×ïhox‹ÒãØ¡D€˜:zè!'óGÑáêÍ�‡·Àå•ø¨ ½ €!‹!"…#%D%X%\%‘%¼%s'¬'-  ± ð8å�ÁöJ	
0
C
1-�»¿Tªy’›¿Ó4AÆs˜è5ÓÒ œ"ç"§$&Ô&Ž'ý(4)?)`)& ÚÒiÇÏë	Ã	
[
´
É
p^(^©Ñrf¸ÓêSÝ3hŸ°!Ü$%�%Ø%5&¬&M)1 7 t þhâ#z+	
¸
ÿ
á“¤7í¢[Ê—ç¬Íùª×²pò7µY– F R!##¶#5%'‚'}(H)Z)Q J Ñ Ù �¤½á¤©�Ùýe´u	ª
: <ä­$>Öúh¢:Ú VNc¯ßz†#cž
L¬¸S§lóû£Æß( k ´ À!")"4"F"å$z%€(g)~) ëV	›	@ËfŸG§+0l4t O#[$½$S)/ % { \ß".˜é�	¶Zöbä–¼ÀÚäCd’PšÍÛòö%@ßG�;~ãN"V"Ì"Œ# $b$P&(1 œ
T}Æ
÷
XmzzÓ+14WJ§
K–œ:m½%l®�,ã,KÖ¾,vÿ!"Š%X&‡), ë &2€†�™°Êq	:j¼ïÄZè+±éþ�¤bõ€Çz¾UúOHT  ï!¶"¿"ë"í$'r((  ýáy€ÀÎê*	�	
Z
ÖînwŠºqìš«òFRgñ4%4%&4&�'�'>)G)L)2 I Ð ›S[ÞU	9;y#=õ*VgÊÙ•›¦9•…+/Úâ+?kò½u}¿!""3"U"R)< …ÈÉS	T	
Y
ìí:hiˆ‰»îUfç°™çè”Ÿ ¡¢£¤¥8¨©ªñQ¡¢£ïð)*N¼!½!¾!""³"´"µ"ì$%2&3&q(K)  6Ø  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                       +                                                                                                                                                                                                                                                                                                                 0                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                %                           1                                                                                          0                                                   
      	   	                	      *                                                                                   -         '         
   	                        E   :      	                                                         %                                  &                  /   '      <         3   5   "      Ò   p      1   .   1   1   "   š                    +                                                                                                                                               0                                                                                                                                                                                                                                                                                                                                        %         1                                0                 
  	 	      	  *                             -   '   
 	        E :  	                   %            &      / '  <   3 5 "  Ò p  1 . 1 1 " š   ¡  ¢­  ¢×  £=  ©»  ±3  ºS
tÖ!pSòÎ úð_ { ½€�Ùpz¶ã#=Öÿ!Wò•©S¥Ff¿òUšö��ßÒ €!’!8"O#è$$íŸ¤øp–Á#oø˜ÒGŽdW@'ñ&?÷<�} Â!¯)	p	¼_%'_ �ó¢!Ý ¦J�Æm<•¦¨¯)	I	p	Í	å	³
,JùŠ´³¼âP¤»FLÁåÑKO«”�:j – ê -!Ÿ!Û#_%�×ß	 …lœ@4 TÑ
«{_=è$2% T®
ÇÀ{µ)=è$ T{=è$^$Ä	—Øå%„&ë'‹!#$n'þ^÷
„_ �b „x<Ùª³�(ç£#)<÷
7…(ÝÖŽ17Ž1õ R²¼Žb&Œêëähž�ª
ÚËxÙê^ûž¢
`7ÀZ&Œú#ƒ\S$”'——Œ¼ª(_àÔ		\	
à•Èƒ(À#³ú†(3UÿÃÉ%bÞbw÷FMÛ8ZË&|,
Fñ6¹M^�Ûp ¹$Â: +!4(ªÎ%C'w{Þ%Ð…²Ã¯6QÏ q&ôKRYò
@V‹Ë(Á<ÜŒ#à†_—'ÎA|Ô		\	
°
à^•È'ƒ(&Ï~úp!±æ¥�
ÀqÌŠØª"3'ˆ'qØª"ˆ'&†ø
ï{ÄHëäYŠ Å ˜%+í/ë„äq%‚ØqQª"ˆ'%¯žŒ˜æ¥�
ë5äéäÈdº‚¯"…'|^ Î
+}:ãð/RA"8(ñ‹ÂÊ"­ä�	Öò%¾IóØ£ÛŒ�`ûy"8#Þ%|^ò d"Øÿúù|Œ�,
ZêëìF·ñž—äå6Œ¤¹MhŸ^�Ûp Ž!µ!¹$%@%&a(Ž«
½Û¢ËxB%<à"&æÚ!õ#Y'*)\&Æèh0%­	Î�A_ e s�áY8å"ý.‡Ã	nw»îïðZz¤géÙè¿zˆ+lªÝ7Ÿû�‡•£k "3G&é(3ì
’~U>"Ñ"&üA#%ÿéÙ%y8ÉžS=%Æì¢‘”²¸»¾V2#�w{…îg1W‰ "ùz
Hw{…!Á"\&ñ&®
Ã	ÝŸ>˜æ/¥�
Àë5„äéäq%‚ÌŠÈØdqºQª"3'ˆ''T@$0(~p!8å".Ã	Z¿+ÝŸ,ö (ª Rñ²ë¼ŽÌØ R–¼Æƒry¯p	Q&*ù›Òó­ˆÊÐìðSKT§ út¸6íŸ ¼ )!!¤!Ô#[%Ã	¤éˆªÝ7Ÿûcu~ðp!­	0  ØOÃØwã
žŒ]
 9ÿRÂúqñ#ü#R$^$^'o'@¸	}ÕDwÉ­v&ÿ$!› ’&å([)ïˆûë�e$x$,'™)˜`;U
¸!J"†%æ¥�
  o J{B‘lÁŽ«
½Û¢<ÜŒ#à†Ë_xB%—'3}€q3E�#Ù#E&×8dYg|#ò
@D	j#ú†(>Šˆm>tÐ4ÀÒ"	t
š
j”#+?Y³^qØóúª"’$ˆ'†(3>«>KÛ9ÉÿTõç\oyp¬µ@lÆçÿfU`¬ Y"ß"A#£#ö#@$C%0(�()¤ú‘."æ";w6Å)ySe°~/ˆ ÇVëûø‡Ò¾ Ä"¹#f'äY&h%¸Ågø
Ø�`°/ÇøÒ¾ #ú†(ø
&æ&<Ú!à"õ#Y'*)J(Z¨tò&ßo‹'¦í!S&	]4	Y¶'8¿A4	„	¥	Ø	'ZáË&³)¦1)Îîz©ð†&°(0 éñØã
žŒ]
 9Rñ#R$^'Œ()¡PÄxŸ�YÃr§#ý#_$/&p'_ e s�áY¤�ÍÙýe´u	ª
oäxÒhÚ˜z'¯áž¸S§�‡•£k ‹!""Ç
±¨é-(¸¾®
h0%-¯²2G|ÇßàbýŸ7œÆïLÏXX¤‘÷OÑÔÀ !#!Æ"#
#Ø# %Ž&¥(b $�—®o	ëì·—äå`iŸc¼àïE„F%f%w%U&ë ¼ïðébë"£%'æÇ	ï
_Ä-Ç&¸'fÐvûX$;%©'�·`cïw%U&¯2G|ÇßbŸœÆÏ‘÷Ñ#
#Ø#Ž&¥(-²àý7ïLXX¤OÔÀ !#!Æ" %Ú´
^¸3%�%¬&� â Bi£?„«üë—£ÌÝ•½ù9V#ñE-¯²Ýv}2G|ÇÝßàbÏý„‡ºŸÂè7Bœ¡ÆïFIL8˜ÁÏXHX¤ýG‘÷0OÑÔÀ !#!&!œ!7"Æ"#
#Ø# %s&Ž&í&Ò'¥(_ e ë s�áY¤�ÍÙýe´u	ª
oäx¼ÒïðhÚé˜z'¯báž¸S§�‡•£k ‹!""ë"£%'0¦ÀÍë�ÁÔRÈ!ä%œ'Ä(Ê	P.œB?>¶&‹ÂãÊ ¡/°"ë+ô ­ä##Ä&!)• {‚	×hØ¡€!óÍ·¨ …#%‘%¼%s'€ á å hƒOÒ›rA–¯¢1Ûµ
SÙ$Ž%­&;)�U³8-×¿wƒ"$Â$Ü�2þÞ&]kˆˆÍ qŒmü“	;
¯èÆ�ª8ØY¶à¥	f	x
ž
t|õ?±“ÃÙM¹Ü÷J!‘!g# $£&�ÜUõ�³8%L2<-×¿þwƒ"$Â$Þ&¾)exuØ@F ÊÙ®Äô‡$³$%w&u ÿ$ ÚÛót—!› !##’&å([)¯R`
°
èÖ!$!Jü'°Êq	Z+þ�UúO  †.áÄ¨Ù @¶–ÕZ£õ	×
T˜v!üT·òDÊ¼4bË !W!ã"è$ƒ)®ÞÉxµÑ÷ùÕ!ï$ö%…(ˆ(l žÛV¶âìˆt¢
±o™„ñ`<”õ.7ŽÀýxÔà!."�#$œ$Z&e&Ý&‰)ßöÚäÍÛòö%V"Œ#P& 
¹œ«‡Ç`>Jå$c%Ç'Ê >G™ðM
RÚ`q�¢ÌÆúð­Ø
Ðì`iÕ"#ˆ#£$î%(&Á&}'²( ª ïRñ ¥¨Î
Ô+¯²»ë+}¼Ž:Ìb#ú#…^-äò÷ U$H'–'(4ã"@¶õ	×
T˜üòb!è$>RÚ`¢ÌúðØ
Ð`î%Á&–ÕZ£v!T·DÊ¼Ë W!ƒ)Ýv}ÝÏ„‡ºÂèB¡FI8˜ÁHýG0&!œ!7"s&í&Ò'u ÿex$uØ@F ÊÙ ®ÄôÚÛót—!‡› !##$³$%w&’&å([)¼>È>Œ€­Ô‹ÍÉ q$DCSF…<£×$&o)”)Ö¦ì'Š(÷~¯&Ç?–‰ ÍíûÃüÖ Ø ž!ã#-%'f(ek~•±½Ër	V
[,ÿWˆ‘»C9f¨ÂIVûHP1‡: ¡ û �!¹!8"K"Ä"¹#,%‡%t&'f'Ó'e(†Ý .vÍ	î	k
™ÝÏ„Š¢Âè¡áFIa˜<Äíý¨Ù ã &!-!B!2#Â#F&í&6(’ 9Àë\B5	N	…	¦	Ù	v
(kG4f¤$N�Ü´[âÌ&´)� Å ,Q±ç¦�Ò?Éù‹‰�
hñ,Tð0Š}¸ßn¨?uÑÈ’‘“ù¯çNsÓ	5 
    ¿ 5!"q"Ÿ" #©%&L&§(.)}ÆÈEž W_ŸÄÎìîÒÂ– × ó !""e"É"w#ä#m%Ê%'g(� õKtý�8Þ
,œm¬±5m–î  _#\$«%î() 1 ¡ÙP<êùƒòÄÙx¥
ä
\Ÿòë�^cYª³: KSÃûr§#ò#ý#$S$_$È$&/&]&_'p'”'�(•()c ¯ $W§x|a—®o	ý
ß&ì>`—åÑ†³ÈÄjŸ°7R¼àÿF…ÑF¡áÐ ~!‰!›!M#%g%r&ì 4zí
½ð9“êÊ	 Mc\ŸTVV ?"Ò"ì"ª#>%`%£%&'Ý ˆ	Ä	)dsUvÞ7ñ*m vÿ¥ q!A$,&6&„&¨&1() A c � œ ¯ Å × $,Q™±ßçï¦»W�§¼Ò?x|a”ÉÜù‹þ$—‰®·o	�
ý
7h�ñ,TZrßð&†áìô06;Šå (>‹§î`}‡¸ßê@n—åd¨?¥ÑøüE†³¹ÈuÄË:jŸÑá6O£¬°Èî:K^�ÉÓä7RV{’¢�¼ej‘£àÿ
F“ªù(c…¯¾Ñçù/FNs¡»Ó	*5á 
   T i  ¿ Ð "!5!~!‰!›!µ!"q"Ÿ"¤"½"#M#X#ƒ# #%%@%Z%^%g%©%&&L&r&§(.)Ý ¨ªkwy~ÿ›µ·½@vóJ /�äìD	F	}	ˆ	�	Ä	…
‡
Ê
%qW)[d®B_ªÒs�ðòUÆ&ÚÜëÔYvÞ7Pñ*r:Mm~—¯ vÿÊÌ¥½  N ] q!±!ú!n"+#A$‰$‹$�$Ý$ &,&6&„&Š&—&¨&ê&!'þ'1(=(«()N)±) Õá
	]	®	
hoá«ˆÏû˜²ÓŽÌ–ÉÖB/$Ï%D'„(Û /¦ú{®IRÙžÌê³âZasž¬Jšárò‘@NÙaýQÈÄÂ «"Ó#"%|%=&•&‰'¤(è(
 õ7Lo¥²Ëi‰{‚œÅÎèú=JSZó
AJ·/WdŒ{X\,1 B � i$›%š&Ì(b)�)¡)œ
T}Æ
÷
XmzzÓ+14WJ§
K–œ:m½%l®�,ã,KÖ¾,vÿ!"Š%X&‡)­ x¢ÓØO‘”ž‘›"‰
á
û
–Mæ‚œÍ4XÐÛŒ™þ²¸»¾ÁÏ%šßà ã!'#·$%*SqŸ}Žšï0ì���5^Zâ'‹ Æ 2$f$k$y$®$™%À%-'š)¬)z � ¥ Å  ,Q±ç¦�Ò?ŒÉêùd‹,|­‰Õá
	]	Œ	®	
€
�
Å
hŸñ,T¶ãð0YŠÒy9h}¦¸ßenÃ6o¨ÂÜ?žá)Jb«Nuˆ®¸ÏÞûL�˜²ÑùyÈÓbŽ’Ì	‘–·ÉÖñk“ÂÕÚÞùœ¯Çç&BNsÓ	5þ 
    ³ ¿ 5!ä!"E"q"}"�"Ÿ"(#‹# #/$Z$¼$©%Ï%&L&D'(„(§(.)f)})N­ËÝƒù
ZÅa$éŠÐl„¨JfpûÔ!x'‡(  3     
”  )Å        )Å�@å­ïÕu¾†âçÝÝCž¿†“EçwÐ= ´f÷‡êçS’}(OFP‘D=eAwÓ¢�þ!>6�‡ðDE"‘ B¡ÓÏ“jÛrÄN6ðIëQxá›£�@z¼à«ÐÈ>àƒûFøÙ”ÓŽª>'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]èTÅ@WÑîìsAì:8S3pÔC1à„œõV¨y0C‘AÄL´šS i1€UZÂ”= VeiWfI€ÔÐ‘q¬Ò–ø>)ÛE$ug€tç_oëGA´QzFÚfYÒM¹¢#mPdFUõ:‘ÔdADÕuRQ÷ÍÓS8n´~FaÖ�…¦efT’Uh_i“}CTEÑUDÒd¨¯ + M7˜Ó-aÎ'CÑÖš.	’4ÓEÖ£„hC5Ón(×·K€6ÔÓ½E¾ TgåAµÓ¾ j £¸{j7Þ8� Xä Ienà]�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›>¥QT  	Ò4Qd‘Ùd×GgW•�UÕ§UkUªÀ©§@tÑÒ¦ÆS ¼Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4NÊ’ËFÏ�ö÷8ª½‘G|{žDš¼!kìCßcø(þï�d&j F©?†µµ®¢û­(N¾öt�t®"Ý eyø`umhJ‚,aKh_Òê<EÿÓ�&­MÞûCþ¦»
'N½V_ø`›yQMN`ïlxôŸÐî?³¨®X�ªX`‹´ ºTÉUUL=ø§Nj Æ&ïtSø-`ö=kM/ÅÒ-#DÑj`!ØÿËJsô‰tÿÑ{ÝâÒ¢>/«ü{!ßAã@ÓÑ ð ´¾:þ4CƒDwøµN í?Œ Ÿç…_ J9`ug¡o°!tç× �(Ý÷M‘è×ÕüD�·ïŽ7¸ÛC¯‹OOÔ¾Óî­†¹Oî¾û< ùˆå&¿ïÏfïø*áTÐ¡KTP:+Â­o‰=•4J8b_å½•ô‹(×ü€áµ•x#�¥Žw� ££óÆ'ß†­¯¸šõHÕ¢r×a‘Ó¨¬9aa+yf='ïUÿNè•l„k?�8ú„ýÙš�øt¥Ôµ>.@±ÔQŽYé¶¹X¶V(_•ë»}IaUéÆ¯\?Õ_{XQDÐQuPSa`RÿÔzòßÏC¨­õ·Ãj �Ý´. ©ôÑ+UãÞ£Oj­Ê4 fô´uÍÒôÞN‚D[‹Ô)ŸuWÕÔB„e,Q!îW¿¾/²8ß…q¬©„Qà€�E:mUšoˆ�ZIQxêï@)U”Z¥cßæÃº� ¹öÜ5Ò1ÀÃÚw�ºôl.3laôtµm}'Ð‚õã…ÍÓçï‰§Ïã�§PaÇC0oÏû¿¿ÿþ\§ƒÅ<èPðˆÊ‹™Šj½öhòêƒX„Á_ƒøºèq6¾@.¯û³Õ�Bâ…‹!AM+î:èQÕ×.$Çú�0_ÿ~t#î0õSÜ‰”g~5C×ý#Ü¢�’ˆÕƒ»íLš×Pý'ý¢`†à°�Øêv"¤±
UW.CÿÅ÷ r
¯¨Uwe:=×Ø8]F�Í
ï:CšÃ˜x×G[;†<ò+Ã‹LÐü+ª‹Qñø¼#øX^4CLÃ› à÷¯£4â;¢ÞÀP9 1Hðï‹nß£¾<EI½¶Ö0Ã�œèo~?k}LWlÛr{<.‹A†àqDÛ@;3ÓÅâ³ÐíC3cñÃnË!ýƒøèñfØ UƒÎ«�­±â Áó›AÙ2ƒŸÈfŽNƒX:û#©Âló¿Í3lúæÏ®‡ºás.Ö×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°8rú½ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.³ë?´q,¿¨>ÿ>¥®4±‘UØ[u$ÖtÓŸXá¢>E7QB«ÒÝûB~¥Xzu8‘ºOz©TU�@å­ï×u¾†âçÝÝCž¿†“EçwÐ= ´f÷‡êçS’}(OFP‘D=eAwÓ¢�þ!>6�‡ðDE"‘ B¡ÓÏ“jÛrÄN6ðIëQxá›£�@z¼à«ÐÈ>àƒûFøÙ”ÓŽª>'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD>‡häÊŸ,~ääNƒ%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy]& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡,plmz*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹�µàeíN_U¶ý^¿Ùþi÷�Z~ «j{•ø†¾áiªÚ¥EhšŠVbyÕé$      i  ‚  )Ä  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  $W<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="20" name="FLAG" directionality="1" translationMW="1012.99" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5379" maxFusedRunOn="5379" detectionMode="exactProteinMatch"><Segment range="5227-5250" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;FLAGÂ® epitope tag, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="USP10" directionality="1" translationMW="87535.82" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5379" maxFusedRunOn="5379"><Segment range="2821-5226" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="18" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7132" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6749" maxFusedRunOn="6749" detectionMode="exactProteinMatch"><Segment range="7133-7144" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8242-8258" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8218-8234" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8311-8332" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="8266-8272" color="#ffffff" type="standard"/><Segment range="8273-8290" color="#ffffff" type="standard"/><Segment name="-35" range="8291-8296" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10240-10344" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2028-2143" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1 (lacking the first T)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="681-806" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10392-10526" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2505-2708" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1303-1536" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2201-2504" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="IRES" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5267-5840" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;internal ribosome entry site (IRES) of the encephalomyocarditis virus (EMCV)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8620-9208" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="4" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6662-7250" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="3' LTR" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7457-8090" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="5' LTR" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-634" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="NeoR/KanR" directionality="1" translationMW="29006.71" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5854-6648" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="10170" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="9379-10170" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="10171-10239" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>77798093-e217-40a0-862c-b592c2701e53</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:44:11">2018.6.12</Created>
<LastModified UTC="9:26:28">2020.1.8</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  <StrandColors><TopStrand><ColorRange range="2820..2848" colors="magenta"/><ColorRange range="3434..3441" colors="magenta"/></TopStrand><BottomStrand><ColorRange range="2820..2848" colors="magenta"/><ColorRange range="3434..3441" colors="magenta"/></BottomStrand></StrandColors>  0ü     
†  )­        )­�@å­ïÕu¾†âçÝÝCž¿†“EçwÐ= ´f÷‡êçS’}(OFP‘D=eAwÓ¢�þ!>6�‡ðDE"‘ B¡ÓÏ“jÛrÄN6ðIëQxá›£�@z¼à«ÐÈ>àƒûFøÙ”ÓŽª>'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]èTÅ@WÑîìsAì:8S3pÔC1à„œõV¨y0C‘AÄL´šS i1€UZÂ”= VeiWfI€ÔÐ‘q¬Ò–ø>)ÛE$ug€tç_oëGA´QzFÚfYÒM¹¢#mPdFUõ:‘ÔdADÕuRQ÷ÍÓS8n´~FaÖ�…¦efT’Uh_i“}CTEÑUDÒd¨¯ + M7˜Ó-aÎ'CÑÖš.	’4ÓEÖ£„hC5Ón(×·K€6ÔÓ½E¾ TgåAµÓ¾ j £¸{j7Þ8� Xä Ienà]�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›>¥QT  	Ò4Qd‘Ùd×GgW•�UÕ§UkUªÀ©§@tÑÒ¦ÆS ¼Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4NÊ’ËFÏ�ö÷8ª½‘G|{žDš¼!kìCßcø(þï�d&j F©?†µµ®¢û­(N¾öt�t®"Ý eyø`umhJ‚,aKh_Òê<EÿÓ�&­MÞûCþ¦»
'N½V_ø`›yQMN`ïlxôŸÐî?³¨®X�ªX`‹´ ºTÉUUL=ø§Nj Æ&ïtSø-`ö=kM/ÅÒ-#DÑj`!ØÿËJsô‰tÿÑ{ÝâÒ¢>/«ü{!ßAã@ÓÑ ð ´¾:þ4CƒDwøµN í?Œ Ÿç…_ J9`ug¡o°!tç× �(Ý÷M‘è×ÕüD�·ïŽ7¸ÛC¯‹OOÔ¾Óî­†¹Oî¾û< ùˆå&¿ïÏfïø*áTÐ¡KTP:+Â­o‰=•4J8b_å½•ô‹(×ü€áµ•x#�¥Žw� ££óÆ'ß†­¯¸šõHÕ¢r×a‘Ó¨¬9aa+yf='ïUÿNè•l„k?�8ú„ýÙš�øt¥Ôµ>.@±ÔQŽYé¶¹X¶V(_•ë»}IaUéÆ¯\?Õ_{XQDÐQuPSa`RÿÔzòßÏC¨­õ·Ãj �Ý´. ©ôÑ+UãÞ£Oj­Ê4 fô´uÍÒôÞN‚D[‹Ô)ŸuWÕÔB„e,Q!îW¿¾/²8ß…q¬©„Qà€�E:mUšoˆ�ZIQxêï@)U”Z¥cßæÃº� ¹öÜ5Ò1ÀÃÚw�ºôl.3laôtµm}'Ð‚õã…ÍÓçï‰§Ïãƒ0oÏû¿¿ÿþ\§ƒÅ<èPðˆÊ‹™Šj½öhòêƒX„Á_ƒøºèq6¾@.¯û³Õ�Bâ…‹!AM+î:èQÕ×.$Çú�0_ÿ~t#î0õSÜ‰”g~5C×ý#Ü¢�’ˆÕƒ»íLš×Pý'ý¢`†à°�Øêv"¤±
UW.CÿÅ÷ r
¯¨Uwe:=×Ø8]F�Í
ï:CšÃ˜x×G[;†<ò+Ã‹LÐü+ª‹Qñø¼#øX^4CLÃ› à÷¯£4â;¢ÞÀP9 1Hðï‹nß£¾<EI½¶Ö0Ã�œèo~?k}LWlÛr{<.‹A†àqDÛ@;3ÓÅâ³ÐíC3cñÃnË!ýƒøèñfØ UƒÎ«�­±â Áó›AÙ2ƒŸÈfŽNƒX:û#©Âló¿Í3lúæÏ®‡ºás.Ö×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°8rú½ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.³ë?´q,¿¨>ÿ>¥®4±‘UØ[u$ÖtÓŸXá¢>E7QB«ÒÝûB~¥Xzu8‘ºOz©TU�@å­ï×u¾†âçÝÝCž¿†“EçwÐ= ´f÷‡êçS’}(OFP‘D=eAwÓ¢�þ!>6�‡ðDE"‘ B¡ÓÏ“jÛrÄN6ðIëQxá›£�@z¼à«ÐÈ>àƒûFøÙ”ÓŽª>'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD>‡häÊŸ,~ääNƒ%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy]& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡,plmz*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹�µàeíN_U¶ý^¿Ùþi÷�Z~ «j{•ø†¾áiªÚ¥EhšŠVbyÕé$      )¬  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  "G<?xml version="1.0"?><Features nextValidID="20"><Feature recentID="19" name="USP10" directionality="1" translationMW="87535.82" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5355" maxFusedRunOn="5355"><Segment range="2821-5226" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="18" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7108" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6725" maxFusedRunOn="6725" detectionMode="exactProteinMatch"><Segment range="7109-7120" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8218-8234" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8194-8210" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8287-8308" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="8242-8248" color="#ffffff" type="standard"/><Segment range="8249-8266" color="#ffffff" type="standard"/><Segment name="-35" range="8267-8272" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10216-10320" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2028-2143" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1 (lacking the first T)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="681-806" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10368-10502" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2505-2708" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1303-1536" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2201-2504" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="IRES" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5243-5816" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;internal ribosome entry site (IRES) of the encephalomyocarditis virus (EMCV)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8596-9184" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="4" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6638-7226" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="3' LTR" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7433-8066" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="5' LTR" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-634" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="NeoR/KanR" directionality="1" translationMW="29006.71" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5830-6624" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="10146" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="9355-10146" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="10147-10215" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>77798093-e217-40a0-862c-b592c2701e53</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:44:11">2018.6.12</Created>
<LastModified UTC="9:26:15">2020.1.8</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  <StrandColors><TopStrand><ColorRange range="2820..2848" colors="magenta"/><ColorRange range="3434..3441" colors="magenta"/></TopStrand><BottomStrand><ColorRange range="2820..2848" colors="magenta"/><ColorRange range="3434..3441" colors="magenta"/></BottomStrand></StrandColors>  0ú     
„  )§        )§�@å­ïÕu¾†âçÝÝCž¿†“EçwÐ= ´f÷‡êçS’}(OFP‘D=eAwÓ¢�þ!>6�‡ðDE"‘ B¡ÓÏ“jÛrÄN6ðIëQxá›£�@z¼à«ÐÈ>àƒûFøÙ”ÓŽª>'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]èTÅ@WÑîìsAì:8S3pÔC1à„œõV¨y0C‘AÄL´šS i1€UZÂ”= VeiWfI€ÔÐ‘q¬Ò–ø>)ÛE$ug€tç_oëGA´QzFÚfYÒM¹¢#mPdFUõ:‘ÔdADÕuRQ÷ÍÓS8n´~FaÖ�…¦efT’Uh_i“}CTEÑUDÒd¨¯ + M7˜Ó-aÎ'CÑÖš.	’4ÓEÖ£„hC5Ón(×·K€6ÔÓ½E¾ TgåAµÓ¾ j £¸{j7Þ8� Xä Ienà]�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›>¥QT  	Ò4Qd‘Ùd×GgW•�UÕ§UkUªÀ©§@tÑÒ¦ÆS ¼Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4NÊ’ËFÏ�ö÷8ª½‘G|{žDš¼!kìF?‚�îø@Òfªj“øak[Zê!ï±ºÒ„ëïgHJâ ÝÐâWŸ†QfÑ„¨"Æ¶…ý!Þ£Ä_ý9ÒjÔÝá´?ájk°¢tëÕeÿ†	·•ÔæöÇ�Iýãû:��JåˆÁJ U†»B u@L•QETÃß�štæ¡Q‚a’n÷E?‚ÖcÖ´Òü]"Ò4A�¦�ü´§?Aè—Oý½Ñî-!Ú#áÒú¿Á7°Òô4= ÿ áªKã¯ãD84G‹PtàÓøÊ	ñžxUú£–Vzû7N}p�ßpTÙ�ý}_ÄHÛ~øáÃp;�´7úø´ôýKà=>êØk”þëï³Â˜�^Rkþüönÿ‚®M
µE¢¼*Ñø“ÙQ£D£�%þ[Ù_H²�ÈYP‚9ÚXçxÐÚ
:?<b}øaJÚû‰¯T�Pú'-wö:ŠÃ–·–cÒ~õ_ñÔî�VÈ@f³ø�¨OÝ™©Ñï‡J]KSâáTEáž�ëk•�ëab…ùQN»·Ô–^œjõÃýU÷°µ…MP…1u ?ð]G¯-üô0jŠÑï[|6ªÛBâ
ŸMµQn=ê4öªÜ£JoKGQœÝ/A�àDè ÔE¸½B™÷U}]D(FRÅàU{ûâû#�øWÊ˜EôS¦ÕY¡fø�è¤•Ž®ô•YEªV=ñ~l;¨ÒŸmÃ]#=§yÑË¯FÂá`àã6ÆGKP†×Ò}!_^8\Ý>~øš|ñ ~80óüÿ»ûÿÿåÊx<SÎ�eŒ¨¹˜¦«ßf�.¨5ˆ@üø?‹®‡käêÿ»=PXÔ.(X²Ò¾àS®…]râL¨ÐÓÿ÷àÇB>ãU=È™FwãT0ÝÒ=Ê!((�Q-X;¾ÔÉ­u áA�ÑBÚ&¸n ûÝŽ§b*K¥Urä?ü_p ªú…Wq†S£Ý}ƒ…Ô`hÜÐ®ðó  D9¬9‡€Ýtu°ã¸cÏ"¼8´Í ÏÂº¨µ‹Â?……ãAÄ4Ì9²qÀÊú3N#±Ê-áLàãš� Ðnø¶íú;ãÄT›Û`á�c8ÙÎ†ðçãö±÷ÔÅvÍ±17'°`SÂè±´nM´³=<^+=Ô36?1ì²Ø1�Ž�m‚X<ê¸Û ðà"9´“(9ü†háDè0Å€áó¯²:œ&Ï;ñ¬Ó6Ï®lúèq+®2à]m~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ S‡/«Ø8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ë>³ûGÁ»ú€óïóàZZãKù]�5·RMgM9õŽ#àäSuA *½-ß´'êQõ‡§PÓ‰¤÷ª•EQ xZÞýqGQ›èn n}ÝÔ9ëøi4^w}ÐFox~ `Žu9'Ò„ôe	CÖT}:)ßâã`DR)*<ù6­· üDãožµŽ±:9Ô«Î z½ƒà0 H1?´o�™M8ê£âx»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„CèvŽL©òÇîNDè2[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘EÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=ørÇÀF×¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸^^Ôåõ[oÕë÷ýŸæŸxõ§â
¶§¹_ˆkîš­ªTV‰¨¥f'�^’      )¦  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  "G<?xml version="1.0"?><Features nextValidID="20"><Feature recentID="19" name="USP10" directionality="1" translationMW="87535.82" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5349" maxFusedRunOn="5349"><Segment range="2815-5220" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="18" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7102" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6719" maxFusedRunOn="6719" detectionMode="exactProteinMatch"><Segment range="7103-7114" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8212-8228" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8188-8204" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8281-8302" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="8236-8242" color="#ffffff" type="standard"/><Segment range="8243-8260" color="#ffffff" type="standard"/><Segment name="-35" range="8261-8266" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10210-10314" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2028-2143" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1 (lacking the first T)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="681-806" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10362-10496" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2505-2708" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1303-1536" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2201-2504" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="IRES" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5237-5810" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;internal ribosome entry site (IRES) of the encephalomyocarditis virus (EMCV)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8590-9178" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="4" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6632-7220" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="3' LTR" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7427-8060" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="5' LTR" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-634" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="NeoR/KanR" directionality="1" translationMW="29006.71" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5824-6618" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="10140" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="9349-10140" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="10141-10209" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>77798093-e217-40a0-862c-b592c2701e53</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:44:11">2018.6.12</Created>
<LastModified UTC="9:25:21">2020.1.8</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  <StrandColors><TopStrand><ColorRange range="2814..2842" colors="magenta"/><ColorRange range="3428..3435" colors="magenta"/></TopStrand><BottomStrand><ColorRange range="2814..2842" colors="magenta"/><ColorRange range="3428..3435" colors="magenta"/></BottomStrand></StrandColors>  0ü     
‡  )³        )³�@å­ïÕu¾†âçÝÝCž¿†“EçwÐ= ´f÷‡êçS’}(OFP‘D=eAwÓ¢�þ!>6�‡ðDE"‘ B¡ÓÏ“jÛrÄN6ðIëQxá›£�@z¼à«ÐÈ>àƒûFøÙ”ÓŽª>'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]èTÅ@WÑîìsAì:8S3pÔC1à„œõV¨y0C‘AÄL´šS i1€UZÂ”= VeiWfI€ÔÐ‘q¬Ò–ø>)ÛE$ug€tç_oëGA´QzFÚfYÒM¹¢#mPdFUõ:‘ÔdADÕuRQ÷ÍÓS8n´~FaÖ�…¦efT’Uh_i“}CTEÑUDÒd¨¯ + M7˜Ó-aÎ'CÑÖš.	’4ÓEÖ£„hC5Ón(×·K€6ÔÓ½E¾ TgåAµÓ¾ j £¸{j7Þ8� Xä Ienà]�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›>¥QT  	Ò4Qd‘Ùd×GgW•�UÕ§UkUªÀ©§@tÑÒ¦ÆS ¼Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4NÊ’ËFÏ�ö÷8ª½‘G|{žDš¼!kìF?‚�îø@Òfªj“øak[Zê!ï±ºÒ„ëïgHJâ ÝÐâWŸ†QfÑ„¨"Æ¶…ý!Þ£Ä_ý9ÒjÔÝá´?ájk°¢tëÕeÿ†	·•ÔæöÇ�Iýãû:��JåˆÁJ U†»B u@L•QETÃß�štæ¡Q‚a’n÷E?‚ÖcÖ´Òü]"Ò4A�¦�ü´§?Aè—Oý½Ñî-!Ú#áÒú¿Á7°Òô4= ÿ áªKã¯ãD84G‹PtàÓøÊ	ñžxUú£–Vzû7N}p�ßpTÙ�ý}_ÄHÛ~øáÃp;�´7úø´ôýKà=>êØk”þëï³Â˜�^Rkþüönÿ‚®M
µE¢¼*Ñø“ÙQ£D£�%þ[Ù_H²�ÈYP‚9ÚXçxÐÚ
:?<b}øaJÚû‰¯T�Pú'-wö:ŠÃ–·–cÒ~õ_ñÔî�VÈ@f³ø�¨OÝ™©Ñï‡J]KSâáTEáž�ëk•�ëab…ùQN»·Ô–^œjõÃýU÷°µ…MP…1u ?ð]G¯-üô0jŠÑï[|6ªÛBâ
ŸMµQn=ê4öªÜ£JoKGQœÝ/A�àDè ÔE¸½B™÷U}]D(FRÅàU{ûâû#�øWÊ˜EôS¦ÕY¡fø�è¤•Ž®ô•YEªV=ñ~l;¨ÒŸmÃ]#=§yÑË¯FÂá`àã6ÆGKP†×Ò}!_^8\Ý>~øš|ñ ~8y+‘0óüÿ»ûÿÿåÊx<SÎ�eŒ¨¹˜¦«ßf�.¨5ˆ@üø?‹®‡käêÿ»=PXÔ.(X²Ò¾àS®…]râL¨ÐÓÿ÷àÇB>ãU=È™FwãT0ÝÒ=Ê!((�Q-X;¾ÔÉ­u áA�ÑBÚ&¸n ûÝŽ§b*K¥Urä?ü_p ªú…Wq†S£Ý}ƒ…Ô`hÜÐ®ðó  D9¬9‡€Ýtu°ã¸cÏ"¼8´Í ÏÂº¨µ‹Â?……ãAÄ4Ì9²qÀÊú3N#±Ê-áLàãš� Ðnø¶íú;ãÄT›Û`á�c8ÙÎ†ðçãö±÷ÔÅvÍ±17'°`SÂè±´nM´³=<^+=Ô36?1ì²Ø1�Ž�m‚X<ê¸Û ðà"9´“(9ü†háDè0Å€áó¯²:œ&Ï;ñ¬Ó6Ï®lúèq+®2à]m~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ S‡/«Ø8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ë>³ûGÁ»ú€óïóàZZãKù]�5·RMgM9õŽ#àäSuA *½-ß´'êQõ‡§PÓ‰¤÷ª•EQ xZÞýqGQ›èn n}ÝÔ9ëøi4^w}ÐFox~ `Žu9'Ò„ôe	CÖT}:)ßâã`DR)*<ù6­· üDãožµŽ±:9Ô«Î z½ƒà0 H1?´o�™M8ê£âx»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„CèvŽL©òÇîNDè2[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘EÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=ørÇÀF×¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸^^Ôåõ[oÕë÷ýŸæŸxõ§â
¶§¹_ˆkîš­ªTV‰¨¥f'�^’      )²  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  "G<?xml version="1.0"?><Features nextValidID="20"><Feature recentID="19" name="USP10" directionality="1" translationMW="87535.82" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5361" maxFusedRunOn="5361"><Segment range="2815-5220" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="18" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7114" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6731" maxFusedRunOn="6731" detectionMode="exactProteinMatch"><Segment range="7115-7126" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8224-8240" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8200-8216" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8293-8314" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="8248-8254" color="#ffffff" type="standard"/><Segment range="8255-8272" color="#ffffff" type="standard"/><Segment name="-35" range="8273-8278" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10222-10326" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2028-2143" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1 (lacking the first T)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="681-806" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10374-10508" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2505-2708" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1303-1536" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2201-2504" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="IRES" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5249-5822" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;internal ribosome entry site (IRES) of the encephalomyocarditis virus (EMCV)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8602-9190" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="4" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6644-7232" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="3' LTR" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7439-8072" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="5' LTR" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-634" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="NeoR/KanR" directionality="1" translationMW="29006.71" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5836-6630" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="10152" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="9361-10152" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="10153-10221" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>77798093-e217-40a0-862c-b592c2701e53</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:44:11">2018.6.12</Created>
<LastModified UTC="9:25:8">2020.1.8</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  <StrandColors><TopStrand><ColorRange range="2814..2842" colors="magenta"/><ColorRange range="3428..3435" colors="magenta"/></TopStrand><BottomStrand><ColorRange range="2814..2842" colors="magenta"/><ColorRange range="3428..3435" colors="magenta"/></BottomStrand></StrandColors>  ,#      .   M         M�@å­ïÕu¾†âçÝÝCž¿†“EçwÐ= ´f÷‡êçS’}(OFP‘D=eAwÓ¢�þ!>6�‡ðDE"‘ B¡ÓÏ“jÛrÄN6ðIëQxá›£�@z¼à«ÐÈ>àƒûFøÙ”ÓŽª>'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]èTÅ@WÑîìsAì:8S3pÔC1à„œõV¨y0C‘AÄL´šS i1€UZÂ”= VeiWfI€ÔÐ‘q¬Ò–ø>)ÛE$ug€tç_oëGA´QzFÚfYÒM¹¢#mPdFUõ:‘ÔdADÕuRQ÷ÍÓS8n´~FaÖ�…¦efT’Uh_i“}CTEÑUDÒd¨¯ + M7˜Ó-aÎ'CÑÖš.	’4ÓEÖ£„hC5Ón(×·K€6ÔÓ½E¾ TgåAµÓ¾ j £¸{j7Þ8� Xä Ienà]�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›>¥QT  	Ò4Qd‘Ùd×GgW•�UÕ§UkUªÀ©§@tÑÒ¦ÆS ¼Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4NÊ’ËFÏ�ö÷8ª½‘G|{žDš¼!kìG’¹0oÏû¿¿ÿþ\§ƒÅ<èPðˆÊ‹™Šj½öhòêƒX„Á_ƒøºèq6¾@.¯û³Õ�Bâ…‹!AM+î:èQÕ×.$Çú�0_ÿ~t#î0õSÜ‰”g~5C×ý#Ü¢�’ˆÕƒ»íLš×Pý'ý¢`†à°�Øêv"¤±
UW.CÿÅ÷ r
¯¨Uwe:=×Ø8]F�Í
ï:CšÃ˜x×G[;†<ò+Ã‹LÐü+ª‹Qñø¼#øX^4CLÃ› à÷¯£4â;¢ÞÀP9 1Hðï‹nß£¾<EI½¶Ö0Ã�œèo~?k}LWlÛr{<.‹A†àqDÛ@;3ÓÅâ³ÐíC3cñÃnË!ýƒøèñfØ UƒÎ«�­±â Áó›AÙ2ƒŸÈfŽNƒX:û#©Âló¿Í3lúæÏ®‡ºás.Ö×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°8rú½ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.³ë?´q,¿¨>ÿ>¥®4±‘UØ[u$ÖtÓŸXá¢>E7QB«ÒÝûB~¥Xzu8‘ºOz©TU�@å­ï×u¾†âçÝÝCž¿†“EçwÐ= ´f÷‡êçS’}(OFP‘D=eAwÓ¢�þ!>6�‡ðDE"‘ B¡ÓÏ“jÛrÄN6ðIëQxá›£�@z¼à«ÐÈ>àƒûFøÙ”ÓŽª>'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD>‡häÊŸ,~ääNƒ%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy]& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡,plmz*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹�µàeíN_U¶ý^¿Ùþi÷�Z~ «j{•ø†¾áiªÚ¥EhšŠVbyÕé$       L  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
   à<?xml version="1.0"?><Features nextValidID="19"><Feature recentID="18" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="4708" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="4325" maxFusedRunOn="4325" detectionMode="exactProteinMatch"><Segment range="4709-4720" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5818-5834" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5794-5810" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5887-5908" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="5842-5848" color="#ffffff" type="standard"/><Segment range="5849-5866" color="#ffffff" type="standard"/><Segment name="-35" range="5867-5872" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7816-7920" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2028-2143" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1 (lacking the first T)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="681-806" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7968-8102" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2505-2708" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1303-1536" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2201-2504" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="IRES" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2843-3416" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;internal ribosome entry site (IRES) of the encephalomyocarditis virus (EMCV)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6196-6784" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="4" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4238-4826" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="3' LTR" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5033-5666" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="5' LTR" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-634" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="NeoR/KanR" directionality="1" translationMW="29006.71" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3430-4224" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7746" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6955-7746" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7747-7815" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>77798093-e217-40a0-862c-b592c2701e53</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:44:11">2018.6.12</Created>
<LastModified UTC="9:24:58">2020.1.8</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  øý7zXZ  æÖ´F !   t/å£à¯V·] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷Ànãý‹v€Ë<2ÇäÄGØARèŒD«Às¿íeÄ±7dž]Ÿ‚¤_“z€ìŒ¥hÝ;Dï3�ýÿx¸G4Îyòpj¾ ¼k„½{"‰µ0 ¶ˆ{æ8ûÅNß+e^–/À`­“ÕW«°´åÿá² ëx»éEf£Þ}—¾«x¨æšÒö3kºj§r™Ô�%1:J÷Ä»á¡†W«s «7�”w:ÙþM=37Tî#ã©oGãùŠŸ‹`øxäµ{ê’LÐä§®žª"ü¸7wI%uçq;„	Hòšêð·ñp—o r±"à”"!©ˆÕƒ.ëýóQ:�ó¸‡%ï’ÁFÓ/cp§ã€èe8M„Îÿ,´Ïä–J©}�Õ°ÎW¬ìÕ/ÊÜ—]SáS]8ÔÕ¬�B¿-ìgæ’_´Ùƒ‹õn"æÂ,€ÁI4È«ÏÁ’«·&Dó­ÿÃ<”yŒí_	ÈÏÛ5_,þ[7Ú�PÈê–^t‹KÁø4Þ—îÍ¢3VÄÜ%vŸ'fÿRxkïÅ³¼Ùk˜„dz®í)V9‘­_ÒÀêât‰Ã @ðS~+£Ígñ‘P•¼šƒé¨
‡:×>m!ÂûúäîÔ9yµË!`ÊIÅFÆñW_ˆZ*FdðÞN‘:QM@Ù™~¿ÖB?-)¦>8Ñ&•êœL©ÒðgYaÜVÉüY3ùŸ �³£ñò:…ù€) .6/‚¤,«ŒEœ†eÎ�2ØYbÁ¤)ÅÏ~(ª×ÈÉ‰÷¾ŠˆJS¼äØcêÚ³¢±avÐx	åÌƒãUæ¾Dsƒ</�õƒ%‡º©7ÍÒÇsÆo�žW€ò{×ÒkaªÌ+òT§¼~_¯ŸNï~h):#LÇ&¤¬BºT:™}Ý�ƒ+üÏ€ìëP�z<`c�=Š>…}v¯/òË×oV!ûÅ÷w¨‰<Yr¾1€˜3”xLséQËB3ç0 (©>JÿX+ÍH ?F›Z‰oxÒ°�Ÿ1x$’†eÄw8YÝ[‰aiq<B·ÎëA' ¼ôéG”‚í lï\~×ÎSÄ¥\NÑçêK�ÍQ�ím/¨’$ôe“«„œÛŠÊ‹uïEÑ,Û4ŒýØ<mY»O…± .
V�"€&§~Ï6ŸÁü§÷‚3µ„ntbK¶�ß�É×´ñ/¥Wšâd?iSLmU,ÊL$²PýºÂÒ¾[•V»+èÞ’©\4Ê£b6r�¨
Ñ�@nœ¶øŠ…Ðª®jÿ¦é 	+½žM±VV¨§ÍcœTö´Çœ¹8üÖ<Dd¼Ü6´{»-œp¸>Ï3é¾ÎH,pÍ<æÌ05_‰«¥Xo’ðnl˜5ôüÄ‹€Pväï~$R7ÿý‚aÏa)%Mvlª“¶†’Þ?Î–3ÆÛ yLÂI(r��¬¬n`èØ °^¡q²£Ì±2ñ¡ôÔÒ]7J»JŸ·R;¥L]yØ~�œ§Y¤4DMŒ25YW-DÐ³“P‘`³ÉAÞáM¯èx¸6—fïÁ¾ŒÑ¸¶›–�´2Ý›ûä ÜÇ•À"™¼
â’½·\%œ¯fÑ …,ðômÖ<ýklªÒz�)>©wYKÎË`�C(\=d÷‡É~ã©"ÑI°£.�Òúæ?3:.Oq,<Š•,†»´xÑ¬ll‰ìf5þèêÇçßh0ë`à4veb¤‰ÕéSÌá sƒ4/Æbâù¦ö0àôQFVºÔdw?ÊFIª @rßú&9ÃÚEX4ßhÂ²ü¹óß¢bÇ_ï#ñÙÊèÈX#ü‰çYbm&g§}ÂAN—ì%sŠ ÇÕì¹€_R€AKZV
j-#}ãh`{“^±ÌtÐÈ¥yë—§ÿ:[\Rá@šÜ=�!u†QkSÎfêªáò ;¯[Þs!LÕ^“Lº2(9Pu0h>×.›ôEOž¦øS_Ú$lË7B�±H)™žŠÿPá, ›UpŸÒ+w…„•¢oÇÁ©“¹§I?ç»Ô-ë¬£Žg—Œ¨.ŸàtäIVvîD8=aƒ:‘èÞ›‡rñã»JÛ‡_]dQ¨ÎÐÄ‚ÓýÞ*ÿR3ù
?d‘4ðÃÖ˜u›Q•iÔÍ<›sÃË�ªWˆb:Ë=5%`"ó6p"ÝÌ'ªqjõ<XPc¾ƒë(þûNÞ”Q(yÁµÛžfGüF¶³ú™E6Z�*R¿ÜþžŸH§…¨Ç	)-s‰ŒwˆâŸýöáƒO“£¨VI˜]ï @y¢Þkøµ¯IÊÖ½Y6…·‹Þ7X5É-Nžá„¶ëC÷+{º{Ê0›ûð¶š$7yÀª³V0[»Ñôä¥0ÍV�“´˜j‚ÄrÂ+‘7–ïßiÅey¬T^É%¥ÉV¹bÀ¬Üó‚š‡:œ¦ÀËl‚Á£·ÞZrvçOOJ‚ñdð&ÅÈ)Dêô'Ò±öh4c„6Kô]­û\¶BzWŽ¶úãØyZÑ)äÕ8¹uÀ‘:ùÄ.|JÈò›.RQ#E‰‹ëE¦¨è¿˜J)&ú‹ÂîU½2â7y u^bê8Ü¹…[Žžïq¸ó'¿1™µ~/ëG»Ôjôõõ‚rh>ÄÓjZaij�€ÐU±Š-9Ü4‰Œd;TV:£ˆ®BVªyô/ØÐ{¥[bVªÆè;hCŒ„–d‚EÞÊÙ>zÑò ‹åQßÞˆ­j™óÑPÌ"á;? ƒP4:HFå Ôá‚Ø¶ç}|	„£ú:6ñAày$’WN‹¯tB¯b‘FMðÕ¶-O´P›è>ÃBþóùxÍa ­3½ª\Œ6�JP¬dzüJ †&=¨ÔH‘ê†¤ŒfbA«µÌh	øñ]-:;ÅEó4÷t> ÔðÙN°ô·ÅÑ�ûqWYÝæú°û ÓìNŒg¿žSY�¶	IÌ¸Ð¢zþå"²ªýÆWÐóù-ª >½¡›sd¨tà±è"7<(mVFp¹o­‘i¢¿Y*…+•ìØP­–ÁÛý¿’éÂT´�¬‰»KŽq+k"V�‡j¾â¶õ'é1í)N‰n¼c6óÝ0Ë|¼e³f¢ò*��X®*U£àŠ¦º÷d´¢ø~|ôí�•Yx�t*zçk}®Õ93:ÄVEWov…ª_ÇÞ(�Šâ”Nk»ÂvánMîOlkº)—ª¡v ½x¦iøµFvS×›û¦øèÉ‚ÑYd6{æò{UuY\’¶«øžïûWŽÒ1Jþ¹$ƒÙ¿~˜V±ûdxÎq˜‹E¾�éê'=Üm8?@öÏ×²{Ë§Åû×½*Ò0ÞxÂè©Z7�]¬hælÐÎ•Ë·{žÊ“St•ö©"k"XhÍÞ"«®¼õÚ{ ÇŽ±tÛ!ZG±ä:DÇ¸aö-ƒ^ƒÇ)G0gO°	Ñ\á™†#Ö$†q(ÇlˆØ÷À(O‘ÿÄüJqQ^m�è•þÝÎDÓb;ëz:¨ó’¼‰õA�v²H.AÿfQ/$Ë"í6˜Ïß(É»£¼ä‹ø T–s–ˆ›_Á”Ãbt½ªèyÊ„2ÚåÞú¦néÞŠ”ekÍ‡ã’½rß|J(™,DUµõ7í7O2Îwz”½u<&“RÊl¡ÜÛÿª¨[Â›’ 17»³m AjFèíÊ"‘ š\„*B¼'?%j~ÙÕE§ ï"”ÍÇÉ‚Ìæt}˜ª)Ðe-ªyì5ù”�¦éZÅxÉ¹KAˆmö/³ë“‚Y¸Íïià¨÷x¢ÚùÇ‚l€¦ê%VA¬Ðÿ„D†êìû‹ýI:�ñÄŠkQyè–Ýnn¿“4ÄŸýF-ó7ìÁúêjÄA6�ÑÞÉÕR’/b¯$ÚÑ’ïæ½ÅßqàK¸—bÜ[ðl¨y&ëD£ˆ9‡o>ÿIÛˆÂ>“÷iM)ø}<3Õ^|óC|F>V¤‘d,÷�Ì·‚Ÿávþ½H-Z›ÿ¤·>xVõ­6èMòõÙ­±í4ZJú˜…&(ïþ’Ðwº5�’u�õ˜Ä)Ç48y*ü÷…a2h2OZè/ë%,‹Î*è7J|é¶Cw¢=ú€ò[qÕÀô„ƒè*î?½QÚä	9.%õ±‡®2ˆ¯É÷‰«ÅêJƒá�Ž¿zb‚;–ô%•}�ÿå›bÙ-OÈÔ‘Ù}ckñôíÌJÈ?ú    @+Než)é Ó×Þ 7´­4±Ägû    YZ  Ù      Ð®ZTR

BASE      º^	  xÁA  „°Y%<0pþ³öX©S$5iŒm[ÛFêbÁ&LØÜÖÂéŒ¹I[ä¦S†´is­•ˆ”kÅ ‡.VÁ˜D°EÛjÍXÐdTZˆÛÒT%‡4¶	‰¸@�”ê‚mlÎÚ’›T«1q@��cå”.¥¡RÎ¥ÎÜV¬ ÍÁZQ´m°X­9©ÕÜ
�Šl �¥èŠ±!9¶Äje,FcN‘ u5a¥,…M’¦Òš´$Š%Á6V-dé4ÅS)ÜHª8EÂ¹&-dkéBšnS-gIQ
—T’U¥ZåbÛjÒt¹©K¢\I„¨kB!¹*'©Ë¶ÃáÐ­hËÁ
�áLgµ¨Dr(Xµ¢-Å’n…

¨-™èt¹°ÄÊ¹dR¢nº&)©Ðt•’Îm²Ø¤ÎM§3­•Žµ46Õ©)cNuµÍ�Ô4� rkÓÚ&QL×H[m¹"Xu0e€Òšm	ª­r1a@®–C6XqIÉV[n©i¬¡èbA›l:×Øh	”n› *‹’ÛÚ,mâ`,¥¡S ÕrnE`¶¨›©+ré¶HEÆØ†„Ó…´�Ð„tÍPÍ‚X.
†å&›V¸É¢€µ: ÈÍ9Qh° pÃØ¦`© 8kÂ‚ ’‚@¨Å‚U ´JÕ!Ü´‰šRÛÖ&á&Z²m«"“škµ%‰6‚¹·%)Û6±-i+Æ”&!Ä0‘¦K\¹ÕJˆ`®)ÔÆP@!j‹4ƒhá\àÔéšÎ–KtÆfÛXájÕR‚Ü˜ Œ-ÓµÂ­€�.·9¥j`l°tÌrnKZÍ¡L,AZ†•¥lˆCÂæ¦Ä¬¹`åÊe2c¡„4¡”†R«(¸\`"éÐéšF+t¹ãDÈ(   �<AlignableSequences trimStringency="Medium"><Sequence name="Copied Sequence" ID="0" sortOrder="0" trimmedRange="17..2393"/></AlignableSequences>  h‹     ÿ BC N srôe”```pðpáó³2Ô3ãö·²*Í+Î/*IMábÊqqQjZjQj^r*ÃqM c@´6   ‹     ÿ BC üíS«%7½mQU©ª#ƒP[�ŠÊl¤Ñ�‰e`¸`ÿw÷LYyáÌÍä&cŸ×_¿þ-ùíóùùûßã¬ÿùõóŸúòáŸ>Ÿ¯ß>Ÿ?ñ6C·Ö%gÎîàÙ×µ¦Í¤¤Þ}lkZ¶œâ�[çà²Á½Ï	‰}bÒ¸¸ƒlN1›Å]ç¬iœ³Hå˜ìöÅ¤*~Ñ©…E¶MvÝ6{fFŸ�BÇðµ›ã’±ðž�¶k”òU4Ü®é]V†)¨ÊbaÕA„[•É'²1¯Kø/-»�³�¬N`¼{æž ø˜˜.3YŽ.’sä8³•<ã ”æÒÑÃ•m×i*6RÄö>Æ>¾·;u™�Œgó9ìâb¡±Ã&çöVüÅ^xŒ¡•˜­Ž«v÷("….í÷axŽ¶©‰yÂqxÈˆ(;%¢#ˆåb4SBº˜Krl­mËGxâ•}h£+«`†pñ½[jæeÝ�Âéë„^K›ÎLdéS`©·¡I4”%¦ð>¹NÚÔº.¬¦½à‚Cº)±§\‰	‡®ø¤Ka£œÐT{Œ’�Žövõ5Ï�ÇÜÒšu[	0(ö8š ›	ôïFlÚ�O&”;@
ªÔàp`—æ*Ž9lš—v²ÜÛŠiÁÃÈ÷y@Eâ"Œ±-èî;Á•á;óÀÇ�wfat&ÚwMŒ·\�¡wRáø!EAfl.�pˆ�Ž£õe�	Ï,”cù“¾2�D™ê«,ÀÿÎíO|XqBPÊÉÈÛ]Ã=.ÝÁ¼aka¦¬>÷ê ‚°…ðN:‹qÞHÊHÍ}4�Ø¦a½úðï¨@ÐÈ{Ô…Ù l=¦¢f0j÷VŽƒd]¦nõjcÏåÙ%ÈÞÕ)Ë‘ ·^�ÆW¶ò\àqŽí>@å¢&Ý£Ž‘Òö"àòýx™]j'vïßßzë­·Þzë­·ÞúÿêÛA:>  ‹     ÿ BC             !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  *l<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="0" name="FLAG" directionality="1" translationMW="1012.99" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5253" maxFusedRunOn="5253" detectionMode="exactProteinMatch"><Segment range="5227-5250" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;FLAGÂ® epitope tag, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="DYKDDDDK"/></Q></Feature><Feature recentID="1" name="USP10" directionality="1" translationMW="87535.82" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5253" maxFusedRunOn="5253"><Segment range="2821-5226" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MPWLPSPGIGQYIFGDFSPDEFNQFFVTPRSSVELPPYSGTVLCGTQAVDKLPDGQEYQRIEFGVDEVIEPSDTLPRTPSYSISSTLNPQAPEFILGCTASKITPDGITKEASYGSIDCQYPGSALALDGSSNVEAEVLENDGVSGGLGQRERKKKKKRPPGYYSYLKDGGDDSISTEALVNGHANSAVPNSVSAEDAEFMGDMPPSVTPRTCNSPQNSTDSVSDIVPDSPFPGALGSDTRTAGQPEGGPGADFGQSCFPAEAGRDTLSRTAGAQPCVGTDTTENLGVANGQILESSGEGTATNGVELHTTESIDLDPTKPESASPPADGTGSASGTLPVSQPKSWASLFHDSKPSSSSPVAYVETKYSPPAISPLVSEKQVEVKEGLVPVSEDPVAIKIAELLENVTLIHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIRPGAAFEPTYIYRLLTVNKSSLSEKGRQEDAEEYLGFILNGLHEEMLNLKKLLSPSNEKLTISNGPKNHSVNEEEQEEQGEGSEDEWEQVGPRNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSSKESATLQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELLSPGVKNKNFKCHRTYRLFAVVYHHGNSATGGHYTTDVFQIGLNGWLRIDDQTVKVINQYQVVKPTAERTAYLLYYRRVDLL"/></Q></Feature><Feature recentID="2" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7134" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6751" maxFusedRunOn="6751" detectionMode="exactProteinMatch"><Segment range="7135-7146" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="IEGR"/></Q></Feature><Feature recentID="3" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8244-8260" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8220-8236" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8313-8334" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="8268-8274" color="#ffffff" type="standard"/><Segment range="8275-8292" color="#ffffff" type="standard"/><Segment name="-35" range="8293-8298" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10242-10346" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2028-2143" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1 (lacking the first T)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="681-806" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10394-10528" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2505-2708" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1303-1536" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2201-2504" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="IRES" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5269-5842" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;internal ribosome entry site (IRES) of the encephalomyocarditis virus (EMCV)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8622-9210" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6664-7252" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="3' LTR" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7459-8092" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="5' LTR" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-634" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="NeoR/KanR" directionality="1" translationMW="29006.71" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5856-6650" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MAEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="20" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="10172" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="9381-10172" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="10173-10241" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature></Features>
  <?xml version="1.0"?><Primers nextValidID="9"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="Primer 2" sequence="taaagattgcagagttgctgg" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="4012-4032" boundStrand="0" annealedBases="taaagattgcagagttgctgg" meltingTemperature="55"><Component hybridizedRange="4012-4032" bases="taaagattgcagagttgctgg"/></BindingSite><BindingSite simplified="1" location="4012-4032" boundStrand="0" annealedBases="taaagattgcagagttgctgg" meltingTemperature="55"><Component hybridizedRange="4012-4032" bases="taaagattgcagagttgctgg"/></BindingSite></Primer><Primer recentID="1" name="Primer 1" sequence="ggtggcgatgatagtatctcc" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="3327-3347" boundStrand="0" annealedBases="ggtggcgatgatagtatctcc" meltingTemperature="57"><Component hybridizedRange="3327-3347" bases="ggtggcgatgatagtatctcc"/></BindingSite><BindingSite simplified="1" location="3327-3347" boundStrand="0" annealedBases="ggtggcgatgatagtatctcc" meltingTemperature="57"><Component hybridizedRange="3327-3347" bases="ggtggcgatgatagtatctcc"/></BindingSite></Primer><Primer recentID="2" name="R3" sequence="cagcaggtccactcggcggtaatac" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="8505-8523" boundStrand="0" annealedBases="cactcggcggtaatac" meltingTemperature="40"><Component bases="cagcaggtc"/><Component hybridizedRange="8505-8509" bases="cactc"/><Component hybridizedRange="8513-8523" bases="ggcggtaatac"/></BindingSite><BindingSite location="5201-5225" boundStrand="1" annealedBases="cagcaggtccactcggcggtaatac" meltingTemperature="64"><Component hybridizedRange="5201-5225" bases="cagcaggtccactcggcggtaatac"/></BindingSite><BindingSite simplified="1" location="8513-8523" boundStrand="0" annealedBases="ggcggtaatac" meltingTemperature="40"><Component bases="cagcaggtccactc"/><Component hybridizedRange="8513-8523" bases="ggcggtaatac"/></BindingSite><BindingSite simplified="1" location="5201-5225" boundStrand="1" annealedBases="cagcaggtccactcggcggtaatac" meltingTemperature="64"><Component hybridizedRange="5201-5225" bases="cagcaggtccactcggcggtaatac"/></BindingSite></Primer><Primer recentID="3" name="D925-R" sequence="tcaggcacaatgtcactgacaga" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="3483-3505" boundStrand="1" annealedBases="tcaggcacaatgtcactgacaga" meltingTemperature="59"><Component hybridizedRange="3483-3505" bases="tcaggcacaatgtcactgacaga"/></BindingSite><BindingSite simplified="1" location="3483-3505" boundStrand="1" annealedBases="tcaggcacaatgtcactgacaga" meltingTemperature="59"><Component hybridizedRange="3483-3505" bases="tcaggcacaatgtcactgacaga"/></BindingSite></Primer><Primer recentID="4" name="R1" sequence="tagcgcggccgctaCTTATCGTCGTCATCCTTGTAATCcagcaggtccactcggcggtaatac" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="8505-8523" boundStrand="0" annealedBases="cactcggcggtaatac" meltingTemperature="40"><Component bases="tagcgcggccgctaCTTATCGTCGTCATCCTTGTAATCcagcaggtc"/><Component hybridizedRange="8505-8509" bases="cactc"/><Component hybridizedRange="8513-8523" bases="ggcggtaatac"/></BindingSite><BindingSite location="5201-5260" boundStrand="1" annealedBases="cgcggccgctaCTTATCGTCGTCATCCTTGTAATCcagcaggtccactcggcggtaatac" meltingTemperature="76"><Component bases="tag"/><Component hybridizedRange="5201-5260" bases="cgcggccgctaCTTATCGTCGTCATCCTTGTAATCcagcaggtccactcggcggtaatac"/></BindingSite><BindingSite simplified="1" location="8513-8523" boundStrand="0" annealedBases="ggcggtaatac" meltingTemperature="40"><Component bases="tagcgcggccgctaCTTATCGTCGTCATCCTTGTAATCcagcaggtccactc"/><Component hybridizedRange="8513-8523" bases="ggcggtaatac"/></BindingSite><BindingSite simplified="1" location="5201-5260" boundStrand="1" annealedBases="cgcggccgctaCTTATCGTCGTCATCCTTGTAATCcagcaggtccactcggcggtaatac" meltingTemperature="76"><Component bases="tag"/><Component hybridizedRange="5201-5260" bases="cgcggccgctaCTTATCGTCGTCATCCTTGTAATCcagcaggtccactcggcggtaatac"/></BindingSite></Primer><Primer recentID="5" name="F3" sequence="gtgacatgcccccgtcagttacgcccaggacttgtaacagcc" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="3424-3465" boundStrand="0" annealedBases="gtgacatgcccccgtcagttacgcccaggacttgtaacagcc" meltingTemperature="74"><Component hybridizedRange="3424-3465" bases="gtgacatgcccccgtcagttacgcccaggacttgtaacagcc"/></BindingSite><BindingSite simplified="1" location="3424-3465" boundStrand="0" annealedBases="gtgacatgcccccgtcagttacgcccaggacttgtaacagcc" meltingTemperature="74"><Component hybridizedRange="3424-3465" bases="gtgacatgcccccgtcagttacgcccaggacttgtaacagcc"/></BindingSite></Primer><Primer recentID="6" name="R2" sequence="gcgtaactgacgggggcatgtcacccataaattctgca" description="&lt;html&gt;&lt;body&gt;&#10;&#10;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="3410-3447" boundStrand="1" annealedBases="gcgtaactgacgggggcatgtcacccataaattctgca" meltingTemperature="70"><Component hybridizedRange="3410-3447" bases="gcgtaactgacgggggcatgtcacccataaattctgca"/></BindingSite><BindingSite simplified="1" location="3410-3447" boundStrand="1" annealedBases="gcgtaactgacgggggcatgtcacccataaattctgca" meltingTemperature="70"><Component hybridizedRange="3410-3447" bases="gcgtaactgacgggggcatgtcacccataaattctgca"/></BindingSite></Primer><Primer recentID="7" name="F2" sequence="tagcctcgaggccaccatgccctggttgccctctcctggaa" description="&lt;html&gt;&lt;body&gt;&#10;&#10;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="2807-2844" boundStrand="0" annealedBases="cctcgaggccaccatgccctggttgccctctcctggaa" meltingTemperature="76"><Component bases="tag"/><Component hybridizedRange="2807-2844" bases="cctcgaggccaccatgccctggttgccctctcctggaa"/></BindingSite><BindingSite simplified="1" location="2807-2844" boundStrand="0" annealedBases="cctcgaggccaccatgccctggttgccctctcctggaa" meltingTemperature="76"><Component bases="tag"/><Component hybridizedRange="2807-2844" bases="cctcgaggccaccatgccctggttgccctctcctggaa"/></BindingSite></Primer><Primer recentID="8" name="F1" sequence="atgccctggttgccctctcctggaatagggcagtatatttttggagattttagccct" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="2820-2876" boundStrand="0" annealedBases="atgccctggttgccctctcctggaatagggcagtatatttttggagattttagccct" meltingTemperature="73"><Component hybridizedRange="2820-2876" bases="atgccctggttgccctctcctggaatagggcagtatatttttggagattttagccct"/></BindingSite><BindingSite simplified="1" location="2820-2876" boundStrand="0" annealedBases="atgccctggttgccctctcctggaatagggcagtatatttttggagattttagccct" meltingTemperature="73"><Component hybridizedRange="2820-2876" bases="atgccctggttgccctctcctggaatagggcagtatatttttggagattttagccct"/></BindingSite></Primer></Primers>
  ¥<Notes>
<UUID>80a5b8d2-adfe-4bb9-9200-c299ad0c4a14</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pLVX-USP10-FLAG-IRES-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="7:44:11">2018.6.12</Created>
<LastModified UTC="17:52:22">2025.8.27</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y      K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                             ¯<StrandColors><TopStrand><ColorRange range="2562..2819" colors="black"/><ColorRange range="2820..2848" colors="magenta"/><ColorRange range="2849..3433" colors="black"/><ColorRange range="3434..3434" colors="magenta"/><ColorRange range="3435..3437" colors="black"/><ColorRange range="3438..3438" colors="magenta"/><ColorRange range="3439..3440" colors="black"/><ColorRange range="3441..3441" colors="magenta"/><ColorRange range="3442..5823" colors="black"/></TopStrand><BottomStrand><ColorRange range="2562..2819" colors="black"/><ColorRange range="2820..2848" colors="magenta"/><ColorRange range="2849..3433" colors="black"/><ColorRange range="3434..3434" colors="magenta"/><ColorRange range="3435..3437" colors="black"/><ColorRange range="3438..3438" colors="magenta"/><ColorRange range="3439..3440" colors="black"/><ColorRange range="3441..3441" colors="magenta"/><ColorRange range="3442..5823" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
